2-[(4-methoxybenzyl)amino]-3-phenyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one hydrochloride | 1016975-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2-[(4-methoxybenzyl)amino]-3-phenyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one hydrochloride
• 英文别名: 2-[(4-Methoxyphenyl)methylamino]-3-phenyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-one;hydrochloride
• CAS: 1016975-36-2
• 化学式: C₂₁H₂₂N₄O₂*ClH
• 分子量: 398.892
• InChiKey: YRLWQPWVHCJCOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.92
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  66
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same
  申请人：Nakamura Keiji

  公开号：US20100093771A1

  公开（公告）日：2010-04-15

  The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein R 1 is lower alkyl, cyclic lower alkyl. etc.; R 2 is H, lower alkyl, lower alkenyl, etc.; R 3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or —N(R 4 )—; R 4 is H or lower, alkyl; or R 2 and R 4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R 5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.
• US8232282B2
  申请人：——

  公开号：US8232282B2

  公开（公告）日：2012-07-31