8-chloro-4-methylchroman | 1314570-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-chloro-4-methylchroman
• 英文别名: 8-chloro-4-methyl-3,4-dihydro-2H-chromene
• CAS: 1314570-62-1
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: AHHHOQZXFMVHSB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  o-chlorophenyl homoallyl ether 在 gold(III) chloride 、 silver trifluoromethanesulfonate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 6.0h， 以68%的产率得到8-chloro-4-methylchroman
  参考文献：
  名称：

  Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies

  摘要：

  We report a gold-catalyzed intramolecular hydroarylation of unactivated olefins using a combination of AuCl(3)/AgOTf as the catalytic system affording dihydrobenzopyrans, tetralins and tetrahydroquinolines in good yields. For our preliminary mechanistic studies, we have investigated the kinetic isotope effects with deuterated arene compounds and found that this catalytic hydroarylation is consistent with an electrophilic aromatic substitution process. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.122

文献信息

• NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES
  申请人：Bayer Animal Health GmbH

  公开号：EP3538512B1

  公开（公告）日：2021-06-16
• [EN] GRK2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE GRK2 ET LEURS UTILISATIONS
  申请人：CYGNAL THERAPEUTICS INC

  公开号：WO2021242844A1

  公开（公告）日：2021-12-02

  The present disclosure features useful methods to treat cancer, e.g., in a subject in need thereof. The methods described herein are useful in the treatment of disorders associated with GRK2 expression, e.g., cancer or cardiovascular disease. The present disclosure also features compounds (e.g., GRK2 inhibitors), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof.