3-羟基亚氨基丙酸 | 62415-63-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-羟基亚氨基丙酸
• 英文名称: formylacetic acid oxime
• 英文别名: 3-hydroxyimino-propionic acid；3-Hydroxyimino-propionsaeure；3-(Hydroxyimino)propanoic acid；3-hydroxyiminopropanoic acid
• CAS: 62415-63-8
• 化学式: C₃H₅NO₃
• mdl: MFCD19228503
• 分子量: 103.078
• InChiKey: XTKKYEXSKPSWOJ-UHFFFAOYSA-N

物化性质

• 沸点：
  346.2±25.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-羟基亚氨基丙酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 β-丙氨酸
  参考文献：
  名称：

  v. Pechmann, Justus Liebigs Annalen der Chemie, 1891, vol. 264, p. 262,272

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-二甲基脲嘧啶 生成 3-羟基亚氨基丙酸
  参考文献：
  名称：

  1,3-二取代的尿嘧啶的碱催化反应。

  摘要：

  DOI：

  10.1021/jo00435a009

文献信息

• Synthesis of phosphinic and phosphoric analogs of aspartic acid
  作者：A. R. Khomutov、T. I. Oslpova、E. N. Khurs、K. V. Alferov、R. M. Khomutov

  DOI：10.1007/bf01457787

  日期：1996.8

  Approaches to the synthesis of 1-amino- and 2-amino-2-carboxyethylphosphinic and-phosphoric acids have been studied. A convenient method for the preparation of phosphinic acids is the reactions of ethyl diethoxymethylphosphonite with ethyl acetamidomethylenemalonate and ethyl 2-acetamidoacrylate.

  已经研究了合成 1-氨基和 2-氨基-2-羧乙基次膦酸和磷酸的方法。制备次膦酸的一种方便的方法是二乙氧基甲基亚膦酸乙酯与乙酰胺基亚甲基丙二酸乙酯和2-乙酰胺基丙烯酸乙酯的反应。
• Determination of Prefracture Physical Function in Community-Dwelling People Who Fracture Their Hip
  作者：T. J. Overend、B. M. Chesworth、M. Sandrin、S. Stroud、R. J. Petrella、R. McCalden

  DOI：10.1093/gerona/55.11.m698

  日期：2000.11.1

  Background, Prefracture physical function must be accurately determined to set appropriate and attainable goals for rehabilitation following hip fracture. This is especially important for people who were living independently prior to their fracture. This study determines reliability and internal consistency of a prefracture physical function questionnaire (PFPFQ) completed by both patients and knowledgeable informants (KIs).Methods. A 20-item PFPFQ, including ambulation, transfers, balance, and self-care domains, was developed using focus groups. Community-dwelling patients with a hip fracture (N = 40, 77.9 +/- 8 years) completed the PFPFQ on two occasions during postoperative acute care. Forty KIs were identified by the patients and also completed the PFPFQ on two occasions via telephone interview. Day-to-day reliability of the patients and KIs [intraclass correlation coefficients (ICC)], and internal consistency [Kuder-Richardson coefficient (KR)] of the PFPFQ were determined.Results. Intrarater reliability was high with ICCs (95% confidence interval) of 0.94 (0.89, 0.96) for patients and 0.96 (0.93, 0.98) for KIs. Interrater reliability on occasion 1 had an ICC of 0.81 (0.69, 0.88). Internal consistency of the patient responses on the first occasion was high (KR coefficient = 0.896).Conclusions. The PFPFQ is a reliable and internally consistent instrument for determining prefracture physical function in community-dwelling people who fracture their hip. In situations where patients with a hip fracture are unable to provide this necessary information, KIs can provide reliable estimates of prefracture function to assist in setting appropriate rehabilitation goals.
• Base-catalyzed reactions of 1,3-disubstituted uracils
  作者：Eva G. Lovett、David Lipkin

  DOI：10.1021/jo00435a009

  日期：1977.7
• v. Pechmann, Justus Liebigs Annalen der Chemie, 1891, vol. 264, p. 262,272
  作者：v. Pechmann

  DOI：——

  日期：——