5-dodec-1-yn-1-yl-2'-C-methyluridine | 1203461-99-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-dodec-1-yn-1-yl-2'-C-methyluridine
• CAS: 1203461-99-7
• 化学式: C₂₂H₃₄N₂O₆
• 分子量: 422.522
• InChiKey: KPLJPFZCFSUCJL-RMEPHLEKSA-N

反应信息

• 作为产物：
  描述：

  [(2R,3R,4R,5R)-3,4-dibenzoyloxy-5-(5-dodec-1-ynyl-2,4-dioxopyrimidin-1-yl)-4-methyloxolan-2-yl]methyl benzoate 在 甲醇 、 氨 作用下， 反应 24.0h， 以32%的产率得到5-dodec-1-yn-1-yl-2'-C-methyluridine
  参考文献：
  名称：

  Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides

  摘要：

  A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.

  DOI：

  10.1080/15257770903128870