methyl 2-{[1-methyl-2-(2-hydroxy-4-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentenedithiocarboxylate | 1173198-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: methyl 2-{[1-methyl-2-(2-hydroxy-4-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentenedithiocarboxylate
• CAS: 1173198-80-5
• 化学式: C₁₈H₂₄N₂O₂S₂
• 分子量: 364.533
• InChiKey: FNXVLASEQMNEJT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  methyl 2-{[1-methyl-2-(2-hydroxy-4-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentenedithiocarboxylate 、 nickel(II) acetate tetrahydrate 以 甲醇 、 氯仿 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  一些新的席夫碱配体提供了NNOS配位球及其镍（II）配合物：合成，表征和配合物形成

  摘要：

  摘要制备了一些新的具有NNOS配位球的四齿配体，并通过元素分析，IR，1H NMR，UV-Vis和质谱对合成的相应镍（II）配合物进行了表征。在DMF溶剂中，在25°C下以0.1 M（NaClO4）恒定的离子强度，通过分光光度法测量了配合物的热力学形成常数。镍的复合物形成趋势如下：[Ni（cdMesalen）]> [Ni（cdsalen）]> [Ni（cdPhsalen）] [Ni（cdMesalMeen）]> [Ni（cdsalMeen）]> [Ni（cdPhsalMeen） ）[Ni（cd5OMesalen）]> [Ni（cd3OMesalen）]> [Ni（cd4OMesalen）]> [Ni（cdsalen）]> [Ni（cd5Brsalen）]> [Ni（cd5Clsalen）]> [ Ni（cd5SO3Nsalen）]> [Ni（cd5SO3Nasalen）] [Ni（cd5OMesalMeen）]>

  DOI：

  10.1016/j.poly.2009.03.018

文献信息

• Synthesis, physical characterization, antibacterial activity and thermodynamic studies of five coodrdinate cobalt(III) Schiff base complexes
  作者：S. Esmaielzadeh、Z. Zare、L. Azimian

  DOI：10.4314/bcse.v30i2.5

  日期：——

  Some five-coordinated cobalt(III) complexes were synthesized and characterized using elemental analysis, 1H NMR and IR spectra. The formation constants and the thermodynamic parameters were measured spectrophotometrically for the 1:1 adduct formation of [Co(Chel)(PBu3)]ClO4.H2O where Chel = cd3OMesalen, cd4OMesalen, cd5OMesalen: methyl-2-[1-methyl-2-(2-hydroxy-3-, 4-, 5-methoxyphenyl)methylidynen-itrilo]ethyl}amino-1-cyclopentene-dithiocarboxylate, as acceptors, with some linear and cyclic amines as donors, in different solvents at constant ionic strength (I = 0.1 M NaClO4), and at various temperatures (T = 283-313 K). The results revealed that the formation constants of the Co(III) Schiff base complexes toward a given amines donor are as follow: [Co(cd4OMesalMeen)(PBu3)]+ > [Co(cd3OMesalMeen)(PBu3)]+ > [Co(cd5OMesalMeen)(PBu3)]+. The trend of the formation constants of the donors (amines) toward a given cobalt(III) complex is as follow: Im > 4-MeIm > BzIm and n-butylamine > sec-butylamine > tert-butylamine. Also the effect of the solvents on the formation constants of a given cobalt(III) Schiff base complex toward a given donor are as follow: CH3CN > DMF > EtOH. The ligands and their cobalt complexes have been screened for their antibacterial activities. All the free Schiff base ligands exhibit higher antibacterial activity than the cobalt(III) complexes.

  利用元素分析、1H NMR 和 IR 光谱合成并表征了一些五配位钴（III）配合物。通过分光光度法测量了 [Co(Chel)(PBu3)]ClO4 的 1:1 加合物形成的形成常数和热力学参数。H2O 其中，Chel = cd3OMesalen、cd4OMesalen、cd5OMesalen：甲基-2-[1-甲基-2-（2-羟基-3-、4-、5-甲氧基苯基）甲基亚硝基氮]乙基}氨基-1-环戊烯-二硫代羧酸酯作为受体，一些线性胺和环状胺作为供体，在不同溶剂中，在恒定离子强度（I = 0.1 M NaClO4）和不同温度（T = 283-313 K）下在不同溶剂中进行。结果表明，Co(III) 希夫碱配合物对特定胺供体的形成常数如下：[Co(cd4OMesalMeen)(PBu3)]+>[Co(cd3OMesalMeen)(PBu3)]+>[Co(cd5OMesalMeen)(PBu3)]+。给体（胺）对特定钴（III）络合物的形成常数趋势如下：Im>4-MeIm>BzIm，正丁胺>仲丁胺>叔丁胺。此外，溶剂对特定钴（III）希夫碱络合物与特定供体的形成常数的影响如下：CH3CN > DMF > EtOH。对配体及其钴配合物进行了抗菌活性筛选。所有游离希夫碱配体的抗菌活性都高于钴（III）配合物。