[Ni(2-hydroxy-1-naphthaldehyde thiosemicarbazone)(triphenylphosphine)]Cl*H2O | 1417424-10-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [Ni(2-hydroxy-1-naphthaldehyde thiosemicarbazone)(triphenylphosphine)]Cl*H2O
• 英文别名: [Ni(Nap-tsc)(PPh3)]Cl.H2O
• CAS: 1417424-10-2
• 化学式: C₃₀H₂₅N₃NiOPS*Cl*H₂O
• 分子量: 618.746
• InChiKey: JCEWIAJUKXVYQJ-FCTFBDSLSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  bis(triphenylphosphine)nickel(II) chloride 、 2-hydroxy-1-naphthaldehyde thiosemicarbazone 、 水 以 乙醇 、 二氯甲烷 为溶剂， 反应 96.0h， 以86%的产率得到[Ni(2-hydroxy-1-naphthaldehyde thiosemicarbazone)(triphenylphosphine)]Cl*H2O
  参考文献：
  名称：

  DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes: synthesis, spectroscopy, electrochemistry, and X-ray crystallography

  摘要：

  Three new nickel(II) thiosemicarbazone complexes have been synthesized and characterized by analytical, spectral, and single-crystal X-ray diffraction studies. In complex 1, the ligand 2-hydroxy-1-naphthaldehydethiosemicarbazone coordinated as a monobasic tridentate donor, whereas in complexes 2 and 3, the ligands salicylaldehyde-4(N)-ethylthiosemicarbazone and 2-hydroxy-1-naphthaldehyde-4(N)-ethylthiosemicarbazone coordinated as a dibasic tridentate donor. The DNA binding ability of the complexes in calf thymus DNA was explored by absorption and emission titration experiments. The antioxidant property of the new complexes was evaluated to test their free-radical scavenging ability. In vitro cytotoxicity assays were performed for the new complexes in A549 and HepG2 cell lines. The new compounds overcome cisplatin resistance in the A549 cell line and they were also active in the HepG2 cell line. The cellular uptake study showed the accumulation of the complexes in tumor cells depended on the nature of the ligand attached to the nickel ion.Structurally different nickel(II) thiosemicarbazone complexes for which DNA binding, antioxidant, cytotoxicity, and cellular uptake studies were performed.

  DOI：

  10.1007/s00775-012-0969-x