O-acetyl 1-naphthohydroxamic acid | 1038403-98-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: O-acetyl 1-naphthohydroxamic acid
• 英文别名: (Naphthalene-1-carbonylamino) acetate
• CAS: 1038403-98-3
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.235
• InChiKey: JASMFYDNEJHPON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O-acetyl 1-naphthohydroxamic acid 、 4-甲苯硼酸 在 噻吩-2-甲酸亚铜(I) 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以65%的产率得到N-(p-tolyl)-1-naphthamide
  参考文献：
  名称：

  N-Amidation by Copper-Mediated Cross-Coupling of Organostannanes or Boronic Acids with O-Acetyl Hydroxamic Acids

  摘要：

  A general nonoxidative N-amidation of organostannanes and boronic acids has been developed. Under nonbasic conditions a wide variety of aryl, alkenyl, and heteroaryl organostannanes and boronic acids couple efficiently with O-acetyl hydroxamic acids in the presence of Cu(I) sources.

  DOI：

  10.1021/ol8009682
• 作为产物：
  描述：

  1-萘羟肟酸 、 乙酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以68%的产率得到O-acetyl 1-naphthohydroxamic acid
  参考文献：
  名称：

  N-Amidation by Copper-Mediated Cross-Coupling of Organostannanes or Boronic Acids with O-Acetyl Hydroxamic Acids

  摘要：

  A general nonoxidative N-amidation of organostannanes and boronic acids has been developed. Under nonbasic conditions a wide variety of aryl, alkenyl, and heteroaryl organostannanes and boronic acids couple efficiently with O-acetyl hydroxamic acids in the presence of Cu(I) sources.

  DOI：

  10.1021/ol8009682

文献信息

• Nucleic acid-induced aggregation of metal nanoparticles and uses thereof in methods for detecting nucleic acids
  申请人：Universitat Rovira I Virgili

  公开号：EP3012221A1

  公开（公告）日：2016-04-27

  The invention relates to an aggregate comprising metallic nanoparticles and nucleic acid molecules wherein each metallic nanoparticle is coated with a polycation. The invention also relates to the a method for obtaining the aggregate of the invention and to the use of said aggregate in methods for detecting the presence of a nucleic acid in a sample, in methods for detecting the presence of a given nucleotide at a predetermined position in a target nucleic acid, in methods for detecting the presence of a modified nucleotide at a predetermined position in a target nucleic acid, methods for detecting the presence of a conjugate between a double stranded nucleic acid and a chemical in a sample comprising double stranded nucleic acid molecules, in methods for determining the content of modified nucleotides in a target nucleic acid and in method for determining the content of modified nucleotides in a target nucleic acid.

  本发明涉及一种由金属纳米颗粒和核酸分子组成的聚合体，其中每个金属纳米颗粒都涂有聚阳离子。本发明还涉及获得本发明聚合体的方法，以及将所述聚合体用于检测样品中是否存在核酸的方法、用于检测目标核酸中预定位置是否存在给定核苷酸的方法、用于检测目标核酸中预定位置是否存在修饰核苷酸的方法、检测包含双链核酸分子的样品中是否存在双链核酸与化学品之间的共轭物的方法、确定靶核酸中修饰核苷酸含量的方法和确定靶核酸中修饰核苷酸含量的方法。
• NUCLEIC ACID-INDUCED AGGREGATION OF METAL NANOPARTICLES AND USES THEREOF IN METHODS FOR DETECTING NUCLEIC ACIDS
  申请人：Universitat Rovira I Virgili

  公开号：EP3209601A1

  公开（公告）日：2017-08-30