3Yjx775vxs | 1995864-97-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3Yjx775vxs
• 英文别名: 1-[(2R,4S,5S)-4-azido-5-(ethoxymethyl)oxolan-2-yl]-3-ethyl-5-methylpyrimidine-2,4-dione
• CAS: 1995864-97-5
• 化学式: C14H21N5O4
• 分子量: 323.35
• InChiKey: BHARZHMUBAZJBJ-QJPTWQEYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  73.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR TREATING RETINAL DEGRADATION
  申请人：University Of Kentucky Research Foundation

  公开号：EP3261644B1

  公开（公告）日：2021-06-02
• Compositions and Methods for Treating Retinal Degradation
  申请人：University of Kentucky Research Foundation

  公开号：US20210220359A1

  公开（公告）日：2021-07-22

  The present disclosure relates to compounds, compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by Alu RNA associated with a cell, for reducing ATP-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species in a cell. The present disclosure further relates to compounds, compositions, and methods for use in protecting an RPE cell and/or for treating, including prophylactic and therapeutic treatment, of conditions associated with retinal damage and/or degradation including, but not limited to, dry age related macular degeneration (AMD) and wet AMD, Alzheimer disease, various forms of arthritis, atherosclerosis, diabetes mellitus, chronic obstructive pulmonary disease, inflammatory bowel disease, and Duchenne muscular dystrophy.