Oleoylcholine | 127165-03-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Oleoylcholine
• 英文别名: trimethyl-[2-[(Z)-octadec-9-enoyl]oxyethyl]azanium
• CAS: 127165-03-1
• 化学式: C23H46NO2+
• 分子量: 368.6
• InChiKey: PVXGXBXEHLTWOE-SEYXRHQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  油酸 、 胆碱 以 甲醇 为溶剂， 生成 Oleoylcholine
  参考文献：
  名称：

  基于离子液体的贴剂配方，用于增强难溶性药物的透皮递送

  摘要：

  [显示省略]

  DOI：

  10.1016/j.molliq.2024.124184

文献信息

• [EN] TOPICAL FORMULATIONS BASED ON IONIC SPECIES FOR SKIN TREATMENT<br/>[FR] FORMULATIONS TOPIQUES A BASE D'ESPÈCES IONIQUES POUR LE TRAITEMENT DE LA PEAU
  申请人：UNIV CALIFORNIA

  公开号：WO2018044920A1

  公开（公告）日：2018-03-08

  Compositions containing a complex that contains a cation with alkyl chains and a macromolecule anion, and methods of making and using are disclosed. The compositions are typically charge neutral and a liquid at room temperature and standard pressure. The macromolecule anions may be nucleic acids, peptides, proteins, and/or carbohydrates. The compositions have enhanced penetration across the skin barrier (stratum corneum) and into the skin cells, delivering the macromolecules to the skin cells. The compositions are topically applied to the skin and are particularly useful for treatment of skin conditions.

  本发明揭示了含有含有烷基链阳离子和大分子阴离子的复合物的组合物及其制备和使用方法。这些组合物通常是电中性的，且在常温和标准压力下呈液态。大分子阴离子可以是核酸、肽、蛋白质和/或碳水化合物。这些组合物可以增强穿透皮肤屏障（角质层）并进入皮肤细胞，将大分子输送到皮肤细胞中。这些组合物可局部应用于皮肤，尤其适用于治疗皮肤状况。
• IONIC LIQUIDS FOR TRANSDERMAL DRUG DELIVERY
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20160263225A1

  公开（公告）日：2016-09-15

  The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

  本文所描述的组合物和方法可通过局部涂抹于皮肤上，对皮肤刺激微乎其微或无刺激作用，并可直接或预防通过皮肤的物质传输。该组合物包含纯离子液体，可选地与待传递的药物结合使用。在一种优选实施例中，该组合物可增加待传递药物的经皮传输。在某些实施例中，该组合物可破坏细菌生物膜。这在抗生素耐药性皮肤感染的治疗中特别有益。在其他实施例中，该组合物可直接在皮肤内传递。在另一些实施例中，该组合物可防止物质通过角质层的传输。所公开的组合物和方法可进行调整和修改，以便用于治疗或预防各种不同的疾病和障碍。
• High density phosphate brines and methods for making and using same
  申请人：Clearwater International LLC

  公开号：EP2264119A1

  公开（公告）日：2010-12-22

  New heavy phosphate brines are disclosed, where the water soluble phosphate brines include two or more metal phosphate. Methods for making and using the heavy phosphate brines in drilling, completion, and fracturing operations are also disclosed.

  公开了新型重磷酸盐盐水，其中水溶性磷酸盐盐水包括两种或两种以上的金属磷酸盐。还公开了在钻井、完井和压裂作业中制造和使用重磷酸盐盐水的方法。
• COMPOSITION CONTAINING ORGANIC AMMONIUM SALT
  申请人：Miyoshi Oil & Fat Co., Ltd.

  公开号：EP3925672A1

  公开（公告）日：2021-12-22

  Provided is a novel composition with excellent stability which contains an organic ammonium salt. The composition containing an organic ammonium salt of the present invention contains an organic ammonium salt having a hydrogen-bonding functional group(s) in a cation and/or an anion, and a surfactant.

  本发明提供了一种稳定性极佳的新型组合物，其中含有一种有机铵盐。 本发明中含有有机铵盐的组合物包含一种在阳离子和/或阴离子中具有氢键官能团的有机铵盐和一种表面活性剂。
• Ionic liquids for transdermal drug delivery
  申请人：The Regents of the University of California

  公开号：US10449254B2

  公开（公告）日：2019-10-22

  The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

  本文所述的组合物和方法可局部用于皮肤，对皮肤的刺激微乎其微或没有刺激，并可引导或阻止通过皮肤的传输。组合物中含有纯净的离子液体，可选择与待输送的药物结合使用。在一个优选的实施方案中，组合物能增加待递送药物的透皮运输。在某些实施方案中，组合物能破坏细菌生物膜。这对治疗抗生素耐药性皮肤感染尤其有益。在其他实施方案中，组合物能引导皮肤内的给药。在另一些实施方案中，组合物可以防止物质通过角质层转移。所公开的组合物和方法可进行调整和修改，从而可用于治疗或预防各种不同的疾病和失调。