N-[2-({[(1S)-2-cyclohexyl-1-methylethyl]amino}methyl)phenyl]-2,2'-bithiophene-5-sulfonamide | 914371-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: N-[2-({[(1S)-2-cyclohexyl-1-methylethyl]amino}methyl)phenyl]-2,2'-bithiophene-5-sulfonamide
• 英文别名: N-[2-[[[(2S)-1-cyclohexylpropan-2-yl]amino]methyl]phenyl]-5-thiophen-2-ylthiophene-2-sulfonamide
• CAS: 914371-28-1
• 化学式: C₂₄H₃₀N₂O₂S₃
• 分子量: 474.712
• InChiKey: MMPUUAPCDKXCGT-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• ANTIMICROBIAL AGENTS
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1879877B1

  公开（公告）日：2013-01-02
• Antimicrobial agents
  申请人：Das Biswajit

  公开号：US20090215764A1

  公开（公告）日：2009-08-27

  Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia , Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton , or Trichosporium . Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.
• US8076370B2
  申请人：——

  公开号：US8076370B2

  公开（公告）日：2011-12-13