| 100839-90-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• CAS: 100839-90-5
• 化学式: C₂H₃O₂*C₁₄H₂₁INO
• 分子量: 401.371
• InChiKey: MDGUBMDOKZNWCH-DIIPUSRUSA-M

反应信息

• 作为产物：
  描述：

  1-methyl-1-<2-(m-iodophenoxy)ethyl>piperidinnium acetate 在 sodium iodide 、 苯甲酸 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以81%的产率得到
  参考文献：
  名称：

  Preparation and evaluation of radioiodinated (iodophenyl)cholines and their morpholinium and piperidinium analogs as myocardial perfusion imaging agents

  摘要：

  A series of nine radioiodinated quaternary ammonium salts related to phenylcholine were synthesized, characterized, and radiolabeled by exchange. These compounds were evaluated as myocardial perfusion imaging agents in mice, pigs, and humans. Mice biodistribution studies showed that five of the nine compounds were taken up in the heart to the same extent as 201Tl+ at 5 min. At 60 min myocardial retention was significantly better than 201Tl+ for six of the compounds. Several of the compounds showed more favorable heart/blood and heart/liver ratios when compared to 201Tl+. Evaluation of three of the more promising compounds in pigs and humans however revealed no selective myocardial uptake.

  DOI：

  10.1021/jm00155a028