3-methyl-1-(oxan-4-yl)-1H-pyrazole | 1339709-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 3-methyl-1-(oxan-4-yl)-1H-pyrazole
• 英文别名: 3-methyl-1-(oxan-4-yl)pyrazole
• CAS: 1339709-68-0
• 化学式: C₉H₁₄N₂O
• 分子量: 166.22
• InChiKey: PCXQLYQQERDIAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS
  申请人：FOGHORN THERAPEUTICS INC

  公开号：WO2019152437A1

  公开（公告）日：2019-08-08

  The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

  本公开涉及用于治疗BAF复合物相关疾病的化合物。
• [EN] INDOLINONE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS<br/>[FR] COMPOSÉS D'INDOLINONE SERVANT D'INHIBITEURS DE MAP4K1
  申请人：ICHNOS SCIENCES S A

  公开号：WO2020070331A1

  公开（公告）日：2020-04-09

  The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring C, X1, X2, L1, R1, R2, R3, R4, R5, R6, R7, m and n are as defined herein, which are useful as MAP4K1 inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by MAP4K1.

  本公开涉及式(I)的化合物及其药用盐，其中环A、环C、X1、X2、L1、R1、R2、R3、R4、R5、R6、R7、m和n如本文所定义，这些化合物可用作MAP4K1抑制剂，其制备方法，包含这些化合物的药物组合物，以及这些化合物或组合物在治疗或预防由MAP4K1介导的各种疾病、症状和/或紊乱中的用途。
• NEW CHEMICAL COMPOUNDS (DERIVATIVES) AND THEIR APPLICATION FOR THE TREATMENT OF ONCOLOGICAL DISEASES
  申请人：LIMITED LIABILITY COMPANY "NATIONAL PHARMACEUTICAL TECHNOLOGIES"

  公开号：US20160200729A1

  公开（公告）日：2016-07-14

  The invention relates to novel chemical compounds of general formula I, in which L A , L B , L C , ring A, ring B, R A , R B , R C , R D , R E and R F have are defined in the description, and which are protein kinases inhibitors. The invention also relates to pharmaceutical compositions containing said compounds and also to the use of said compounds for treatment and/or prevention of diseases related with aberrant protein kinase activity.
• US9695182B2
  申请人：——

  公开号：US9695182B2

  公开（公告）日：2017-07-04
• [EN] HPK1 ANTAGONISTS AND USES THEREOF<br/>[FR] ANTAGONISTES DE HPK1 ET LEURS UTILISATIONS
  申请人：NIMBUS SATURN INC

  公开号：WO2021050964A1

  公开（公告）日：2021-03-18

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.