7β-carboxymethyl-17-hydroxy-4-pregnene-3,20-dione | 64709-14-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7β-carboxymethyl-17-hydroxy-4-pregnene-3,20-dione
• 英文别名: 2-[(7R,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-7-yl]acetic acid
• CAS: 64709-14-4
• 化学式: C₂₃H₃₂O₅
• 分子量: 388.504
• InChiKey: AECQIRNVHINZFH-KSJIGVLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7β-carboxymethyl-17-hydroxy-5-pregnene-3,20-dione 3,20-bisethylene ketal 在 硫酸 作用下， 以 丙酮 为溶剂， 反应 1.5h， 生成 7β-carboxymethyl-17-hydroxy-4-pregnene-3,20-dione
  参考文献：
  名称：

  7α- and 7β-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol. Synthesis and immunogenic properties

  摘要：

  7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers were used for immunization. In both cases, highly specific antisera were obtained which may possibly be used to assay human plasma 17-hydroxyprogesterone and 11-deoxycortisol without chromatographic purification.

  DOI：

  10.1016/0039-128x(80)90112-9

文献信息

• COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS
  申请人：Miller Freda

  公开号：US20110301105A1

  公开（公告）日：2011-12-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.
• US8748177B2
  申请人：——

  公开号：US8748177B2

  公开（公告）日：2014-06-10