1-Methyl-3-[1-(oxane-4-carbonyl)-2,3-dihydroimidazo[1,2-b]pyrazol-6-yl]urea | 1209487-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 1-Methyl-3-[1-(oxane-4-carbonyl)-2,3-dihydroimidazo[1,2-b]pyrazol-6-yl]urea
• CAS: 1209487-34-2
• 化学式: C₁₃H₁₉N₅O₃
• 分子量: 293.326
• InChiKey: IXJLUBYNSFQYAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
  申请人：Mitsuoka Yasunori

  公开号：US20110230472A1

  公开（公告）日：2011-09-22

  It is an object of the present invention to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused azole compound shown in the present specification, or a pharmaceutically acceptable salt thereof.