N-but-3-enylnaphthalen-1-amine | 1341910-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-but-3-enylnaphthalen-1-amine
• CAS: 1341910-45-9
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: PHPXMGOMPFQCKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-but-3-enylnaphthalen-1-amine 、 3-butynoyl chloride 以 二氯甲烷 为溶剂， 反应 2.0h， 以42%的产率得到
  参考文献：
  名称：

  Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

  摘要：

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.

  DOI：

  10.1021/ol302680m
• 作为产物：
  描述：

  4-溴-1-丁烯 、 1-萘胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以20%的产率得到N-but-3-enylnaphthalen-1-amine
  参考文献：
  名称：

  Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts

  摘要：

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.

  DOI：

  10.1021/ol302680m

文献信息

• Complex Polycyclic Scaffolds by Metathesis Rearrangement of Himbert Arene/Allene Cycloadducts
  作者：Jonathan K. Lam、Yvonne Schmidt、Christopher D. Vanderwal

  DOI：10.1021/ol302680m

  日期：2012.11.2

  The intramolecular arene/allene cycloaddition first described 30 years ago by Himbert and Henn permits rapid access to strained polycyclic compounds. Alkene metathesis processes cleanly rearrange appropriately substituted cycloadducts into complex, functional-group-rich polycyclic lactams of potential utility for natural product synthesis and medicinal chemistry.