2-cyclohexylidene-N-(2,4-dihydroxyphenyl)acetamide | 340706-13-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-cyclohexylidene-N-(2,4-dihydroxyphenyl)acetamide
• CAS: 340706-13-0
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: JZQBKTNNBDLVGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS
  申请人：Novartis AG

  公开号：EP1230227A1

  公开（公告）日：2002-08-14
• US6716865B1
  申请人：——

  公开号：US6716865B1

  公开（公告）日：2004-04-06
• [EN] BENZOXA- AND BENZTHIAZOLES<br/>[FR] BENZOXATHIAZOLES ET BENZTHIAZOLES
  申请人：NOVARTIS AG

  公开号：WO2001036398A1

  公开（公告）日：2001-05-25

  Benzoxa- and benzthiazoles substituted at the 2 position and carrying a sulfamic acid ester group bound via oxygen to the phenyl part of the ring structure, such as the compounds of formula (I) wherein the symbols have various significances, possess interesting pharmacological activity. They can be prepared by sulfamoylation of a corresponding compound carrying a hydroxy group on the phenyl part of the ring structure, or by N-substitution. They are indicated for use as steroid sulfatase inhibitors in the prevention and treatment of illnesses responsive to steroid sulfatase inhibition, such as acne.