3,5-diacetoxy-2-bromo-[1,4]naphthoquinone | 161621-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,5-diacetoxy-2-bromo-[1,4]naphthoquinone
• 英文别名: 3,5-Diacetoxy-2-brom-[1,4]naphthochinon
• CAS: 161621-00-7
• 化学式: C₁₄H₉BrO₆
• 分子量: 353.126
• InChiKey: KMXWDGXMJMSPFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  21.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  86.74
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  3,5-diacetoxy-2-bromo-[1,4]naphthoquinone 、 (2-三甲基stannanyl-苯基)-carbamic acid 叔丁酯 在 四(三苯基膦)钯 、 copper(I) bromide 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 以60%的产率得到2-<2-<(tert-Butoxycarbonyl)amino>phenyl>-3,5-bis(acetyloxy)-1,4-naphthoquinone
  参考文献：
  名称：

  Synthesis of Antibiotics WS 5995 A and C and Related Compounds by Palladium-Catalyzed Coupling of 2-Bromonaphthoquinones with Organostannanes

  摘要：

  The synthesis of arylnaphthoquinones can be performed simply by using as the key reaction the Pd(0)- and Cu(I)-catalyzed coupling of arylstannanes with 2-bromonaphthoquinones as the electrophiles. The palladium-catalyzed coupling reaction is general and allows for the functionalization of the unprotected quinone nucleus with alkyl, alkenyl, and aryl substituents. The coupling process tolerates the presence of a chelated peri hydroxyl and steric crowding of a 2,6-disubstituted arylstannane, although the preparation of a 2,6,2',6'-tetrasubstituted biaryl by coupling of 2-bromo-3,5-bis(acetyloxy)-1,4-naphthoquinone as the electrophile with 2,6-disubstituted arylstannanes was unsuccessful. The syntheses of quinonoid antibiotics WS 5995 A and C was accomplished by using this method as the key step. Benz[b]phenanthridinone 1, hypothetical intermediate in the biosynthesis of benz[b]phenanthridine alkaloids, was also prepared from antibiotic WS 5995 C or by addition of ammonia to the 2-aryl-1,4-naphthoquinone 41 followed by heterocyclization.

  DOI：

  10.1021/jo00099a045
• 作为产物：
  描述：

  2-bromo-5-hydroxy-[1,4]naphthoquinone 在 sodium hydroxide 、 硫酸 、 溴 作用下， 生成 3,5-diacetoxy-2-bromo-[1,4]naphthoquinone
  参考文献：
  名称：

  Synthesis of Antibiotics WS 5995 A and C and Related Compounds by Palladium-Catalyzed Coupling of 2-Bromonaphthoquinones with Organostannanes

  摘要：

  The synthesis of arylnaphthoquinones can be performed simply by using as the key reaction the Pd(0)- and Cu(I)-catalyzed coupling of arylstannanes with 2-bromonaphthoquinones as the electrophiles. The palladium-catalyzed coupling reaction is general and allows for the functionalization of the unprotected quinone nucleus with alkyl, alkenyl, and aryl substituents. The coupling process tolerates the presence of a chelated peri hydroxyl and steric crowding of a 2,6-disubstituted arylstannane, although the preparation of a 2,6,2',6'-tetrasubstituted biaryl by coupling of 2-bromo-3,5-bis(acetyloxy)-1,4-naphthoquinone as the electrophile with 2,6-disubstituted arylstannanes was unsuccessful. The syntheses of quinonoid antibiotics WS 5995 A and C was accomplished by using this method as the key step. Benz[b]phenanthridinone 1, hypothetical intermediate in the biosynthesis of benz[b]phenanthridine alkaloids, was also prepared from antibiotic WS 5995 C or by addition of ammonia to the 2-aryl-1,4-naphthoquinone 41 followed by heterocyclization.

  DOI：

  10.1021/jo00099a045

文献信息

• STUDIES IN THE JUGLONE SERIES. II. HYDROXY AND HYDROXYHALOGENO DERIVATIVES
  作者：R. H. THOMSON

  DOI：10.1021/jo01164a015

  日期：1948.11