1-Pentan-3-ylazetidine-3-carboxylic acid | 1127402-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 1-Pentan-3-ylazetidine-3-carboxylic acid
• CAS: 1127402-07-6
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: AVTULLAVMIGJFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NEW TETRACYCLINE DERIVATIVES AS ANTIINFECTIVE AGENTS<br/>[FR] NOUVEAU DÉRIVÉS DE TÉTRACYCLINE EN TANT QU'AGENTS ANTI-INFECTIEUX
  申请人：REDDYS LAB LTD DR

  公开号：WO2009032326A1

  公开（公告）日：2009-03-12

  In accordance with one embodiment, the present invention provides a compound of general formula (I), stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds.

  根据一种实施例，本发明提供了通式（I）的化合物，其立体异构体和/或其药学上可接受的盐，具有抗菌活性；采用这些新化合物治疗温血动物感染性疾病的方法。
• Alkoxy indolinone based protein kinase inhibitors
  申请人：Liang Congxin

  公开号：US20070072934A1

  公开（公告）日：2007-03-29

  Alkoxy indolinone based acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  基于Alkoxy吲哚酮的酸和酰胺衍生物具有增强和意想不到的药物特性，可作为蛋白激酶抑制剂，并可用于治疗与异常蛋白激酶活性相关的疾病，如癌症。
• Enhanced Indolinone Based Protein Kinase Inhibitors
  申请人：Liang Congxin

  公开号：US20100267719A1

  公开（公告）日：2010-10-21

  Alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl)amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  Alpha-hydroxy-omega-(2-oxo-indolylidenemethyl-pyrrole-3′-carbonyl)amino烷基酸和酰胺衍生物具有增强和意外的药物特性，可作为蛋白激酶抑制剂用于治疗与异常蛋白激酶活性相关的疾病，如癌症。
• Polyene macrolide derivative
  申请人：Shionogi & Co., Ltd.

  公开号：US10696707B2

  公开（公告）日：2020-06-30

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

  本发明是以下两性霉素 B 衍生物： 其中各符号在说明中定义。本发明化合物的第 16 位（X）是脲结构、环状结构、羟烷基或取代的单烷基氨基甲酰基。本发明化合物具有抗真菌活性。
• POLYENE MACROLIDE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：US20190135847A1

  公开（公告）日：2019-05-09

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.