CGP-74514A hydrochloride | 481724-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: CGP-74514A hydrochloride
• 英文别名: 2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine;hydrochloride
• CAS: 481724-82-7
• 化学式: C19H25Cl2N7
• 分子量: 422.4
• InChiKey: GDCXPZPXAWTYJM-LDXVYITESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.35
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  93.7
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Neurofibromatoses therapeutic agents and screening for same
  申请人：Fernandez-Valle Cristina

  公开号：US10105351B2

  公开（公告）日：2018-10-23

  Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a modulator of a target related to neurofibromatosis. Also disclosed are screening assays involving the implementation of Merlin-null Schwann cells, and to compounds identified using same.

  本文公开了治疗有患神经纤维瘤病或散发性分裂瘤风险的患者的方法。在示例性实施方案中，该方法涉及向有需要的受试者施用有效量的神经纤维瘤病相关靶点的调节剂。还公开了涉及实施Merlin-null许旺细胞的筛选试验，以及利用这些试验鉴定的化合物。
• NEUROFIBROMATOSES THERAPEUTIC AGENTS AND SCREENING FOR SAME
  申请人：University of Central Florida Research Foundation, Inc.

  公开号：EP2825209A1

  公开（公告）日：2015-01-21
• Cancer stem cell immortalization
  申请人：Prochownik Edward A.

  公开号：US20110244472A1

  公开（公告）日：2011-10-06

  The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a patient and used, according to the invention, to select agents more likely to be effective in treating the cancer of that particular patient.
• [EN] CANCER STEM CELL IMMORTALIZATION<br/>[FR] IMMORTALISATION DE CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV PITTSBURGH

  公开号：WO2009140260A2

  公开（公告）日：2009-11-19

  The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a patient and used, according to the invention, to select agents more likely to be effective in treating the cancer of that particular patient.
• [EN] NEUROFIBROMATOSES THERAPEUTIC AGENTS AND SCREENING FOR SAME<br/>[FR] AGENTS THÉRAPEUTIQUES POUR LA NEUROFIBROMATOSE ET CRIBLAGE DE CEUX-CI
  申请人：UNIV CENTRAL FLORIDA RES FOUND

  公开号：WO2013138463A1

  公开（公告）日：2013-09-19

  Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a modulator of a target related to neurofibromatosis. Also disclosed are screening assays involving the implementation of Merlin- null Schwann cells, and to compounds identified using same.