1-[4-(Hydroxymethyl)phenyl]-2-phenylethanone | 147056-27-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[4-(Hydroxymethyl)phenyl]-2-phenylethanone
• CAS: 147056-27-7
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: SLEWKBUAIVFEDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-[4-(Hydroxymethyl)phenyl]-2-phenylethanone 在 potassium hydrogencarbonate 、 二甲基亚砜 作用下， 以94%的产率得到4-(hydroxymethyl)benzil
  参考文献：
  名称：

  An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: a new facet to classical DMSO oxidation

  摘要：

  一个在概念上全新的二甲基亚砜（DMSO）基氧化过程已经被证明可以在不使用任何活化剂的情况下氧化活性亚甲基和苯甲醇。

  DOI：

  10.1039/c5cc05713b

文献信息

• [EN] INHIBITORS OF AKT ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITÉ AKT
  申请人：MERCK SHARP & DOHME

  公开号：WO2010104933A1

  公开（公告）日：2010-09-16

  The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

  这项即时发明提供了替代的融合萘啉衍生物，可以抑制Akt活性。具体来说，所披露的化合物选择性地抑制Akt同工型中的一个或两个。该发明还提供了包含这种抑制性化合物的组合物，以及通过向需要治疗癌症的患者施用该化合物来抑制Akt活性的方法。
• Thiazole Compounds and Uses Thereof
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：US20150119430A1

  公开（公告）日：2015-04-30

  The present invention relates to a compound of Formula (I), or an isomer, pharmaceutically acceptable salt and solvate thereof; the present invention further relates to a pharmaceutical composition, which comprises the compound of Formula (I), or isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents; the present invention further relates to the use of the compound of Formula (I), or isomer, pharmaceutically acceptable salt or solvate thereof, for anti-apoptosis, prophylaxis or treatment of a disease or symptom associated with apoptosis, especially for protecting myocardial cells, and prophylaxis or treatment of a disease or symptom associated with cardiomyocyte apoptosis.

  本发明涉及一种式（I）的化合物，或其异构体，药学上可接受的盐和溶剂化物；本发明进一步涉及一种药物组合物，该药物组合物包括式（I）的化合物，或其异构体，药学上可接受的盐或溶剂化物，以及药学上可接受的载体、赋形剂或稀释剂；本发明进一步涉及使用式（I）的化合物，或其异构体，药学上可接受的盐或溶剂化物，用于抗凋亡、预防或治疗与凋亡相关的疾病或症状，特别是用于保护心肌细胞，以及预防或治疗与心肌细胞凋亡相关的疾病或症状。
• INHIBITORS OF AKT ACTIVITY
  申请人：Fan Weiming

  公开号：US20120004240A1

  公开（公告）日：2012-01-05

  The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

  本发明提供了取代的融合萘啉衍生物，可抑制Akt活性。特别地，所披露的化合物选择性地抑制一种或两种Akt同工型。本发明还提供了包含这种抑制剂化合物的组合物以及通过向需要治疗癌症的患者施用该化合物来抑制Akt活性的方法。
• US9139543B2
  申请人：——

  公开号：US9139543B2

  公开（公告）日：2015-09-22
• An unusual chemoselective oxidation strategy by an unprecedented exploration of an electrophilic center of DMSO: a new facet to classical DMSO oxidation
  作者：Rajesh Chebolu、Ashish Bahuguna、Reena Sharma、Vivek Kumar Mishra、P. C. Ravikumar

  DOI：10.1039/c5cc05713b

  日期：——

  A conceptually new dimethyl sulfoxide (DMSO) based oxidation process without the use of any activator has been demonstrated for the oxidation of active methylenes and benzhydrols.

  一个在概念上全新的二甲基亚砜（DMSO）基氧化过程已经被证明可以在不使用任何活化剂的情况下氧化活性亚甲基和苯甲醇。