7-chloro-6-fluoro-1-(pyridin-3-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 1339961-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-chloro-6-fluoro-1-(pyridin-3-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• CAS: 1339961-21-5
• 化学式: C₁₄H₇ClFN₃O₃
• 分子量: 319.679
• InChiKey: JZGZHHHCJGOINP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.27
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.08
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  7-chloro-6-fluoro-1-(pyridin-3-yl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 、 4-methoxymino-7-oxo-8-oxa-2,6-diazaspiro[4.5]decane mesylate 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of naphthyridone derivatives containing 8-alkoxyimino-1,6-dizaspiro[3.4]octane scaffolds

  摘要：

  The synthesis of naphthyridone derivatives containing 8-alkoxyimino-1.6-dizaspiro[3.4]octane scaffolds, the position isomers of the side chain at the C-7 position of Zabofloxacin, has been achieved in eight steps from tert-butyl 3-cyano-4-oxopyrrolidine-1-carboxylate. The possible reaction mechanisms were also proposed. The key spirocyclic carbamate esters, which could be prepared using a modified Hofmann rearrangement strategy, were condensed with naphthyridone nuclei, and the resulting condensates were easily cleaved by TMSI and subsequently cyclized in the presence of K(2)CO(3). Moreover, additional N-methylation derivatives were also obtained using the synthetic sequence. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.089