5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-5-(2-pyridinylmethyl)- | 1642857-70-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5H-Pyrrolo[3,2-d]pyrimidin-2-amine, 4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-5-(2-pyridinylmethyl)-
• 英文别名: 4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-5-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-2-amine
• CAS: 1642857-70-2
• 化学式: C₁₆H₁₅N₇O₂
• 分子量: 337.34
• InChiKey: IDAXSJSJUWMJSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
  申请人：Janssen Sciences Ireland Unlimited Company

  公开号：US10385054B2

  公开（公告）日：2019-08-20

  This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.

  本发明涉及吡咯并[3,2-d]嘧啶衍生物、其制备工艺、药物组合物及其在治疗和/或治疗疾病中的用途。
• Pyrrolo [3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
  申请人：JANSSEN SCIENCES IRELAND UNLIMITED COMPANY

  公开号：US10781216B2

  公开（公告）日：2020-09-22

  This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.

  本发明涉及吡咯并[3,2-d]嘧啶衍生物、其制备工艺、药物组合物及其在治疗和/或治疗疾病中的用途。
• EP3030563B1
  申请人：——

  公开号：EP3030563B1

  公开（公告）日：2017-08-09
• PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20160168150A1

  公开（公告）日：2016-06-16

  This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.