3-Diethylamino-butanol-(1) | 90225-55-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Diethylamino-butanol-(1)
• 英文别名: 3-diethylamino-butan-1-ol；γ-Diaethylamino-butylalkohol；3-Diaethylamino-butan-1-ol；3-(Diethylamino)butan-1-ol
• CAS: 90225-55-1
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: IVFPTNHGDLCNBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium amalgam 、 溶剂黄146 作用下， 生成 3-Diethylamino-butanol-(1)
  参考文献：
  名称：

  Mannich; Horkheimer, Archiv der Pharmazie, 1926, p. 179

  摘要：

  DOI：

文献信息

• [EN] QUINAZOLINE DERIVATIVES<br/>[FR] DERIVES DE QUINAZOLINE
  申请人：ZENECA LIMITED

  公开号：WO1996033980A1

  公开（公告）日：1996-10-31

  (EN) The invention concerns quinazoline derivatives of the formula (I) wherein n is 1, 2 or 3 and each R2 is independently halogeno, trifluoromethyl or (1-4C)alkyl; R3 is (1-4C)alkoxy; and R1 is di-[(1-4C)alkyl]amino-(2-4C)alkoxy, pyrrolidin-1-yl-(2-4C)alkoxy, piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy, 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy, imidazol-1-yl-(2-4C)alkoxy, di-[(1-4C)alkoxy-(2-4C)alkoxyl]amino-(2-4C)alkoxy, thiamorpholino-(2-4C)alkoxy, 1-oxothiamorpholino-(2-4C)alkoxy or 1,1-dioxothiamorpholino-(2-4C)alkoxy, and wherein any of the above-mentioned R1 substituents comprising a CH2 (methylene) group which is not attached to a N or O atom optionally bears on said CH2 group a hydroxy substituent; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.(FR) L'invention concerne des dérivés de quinazoline de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci. Dans la formule (I), n vaut 1, 2 ou 3 et chaque R2 représente séparément halogéno, trifluorométhyle ou alkyle (1-4C); R3 représente alcoxy (1-4C); et R1 représente di[alkyl(1-4C)]amino-alcoxy(2-4C), pyrrolidin-1-yl-alcoxy(2-4C), pipéridino-alcoxy(2-4C), morpholino-alcoxy(2-4C), pipérazin-1-yl-alcoxy(2-4C), 4-alkylpipérazin(1-4C)-1-yl-alcoxy(2-4C), imidazol-1-yl-alcoxy(2-4C), di[alcoxy(1-4C)-alkyl(2-4C)]amino-alcoxy(2-4C), thiamorpholino-alcoxy(2-4C), 1-oxothiamorpholino-alcoxy(2-4C) ou 1,1-dioxothiamorpholino-alcoxy(2-4C), et dans laquelle les substituants de R1 susmentionnés comprenant un groupe CH¿2(méthylène) qui n'est pas attaché à un atome N ou O porte éventuellement sur ledit groupe CH2 un substituant hydroxy. L'invention porte aussi sur des procédés de préparation desdits composés, des compositions pharmaceutiques les contenant et l'utilisation des propriétés inhibitrices de la tyrosine-kinase réceptrice du composé dans le traitement de maladies prolifératives telles que le cancer.

  本发明涉及式(I)的喹唑啉衍生物，其中n为1、2或3，每个R2独立地为卤素、三氟甲基或(1-4C)烷基；R3为(1-4C)烷氧基；R1为双[(1-4C)烷基]氨基-(2-4C)烷氧基、吡咯烷-1-基-(2-4C)烷氧基、哌啶-(2-4C)烷氧基、吗啉-(2-4C)烷氧基、哌嗪-1-基-(2-4C)烷氧基、4-(1-4C)烷基哌嗪-1-基-(2-4C)烷氧基、咪唑-1-基-(2-4C)烷氧基、双[(1-4C)烷氧基-(2-4C)烷氧基]氨基-(2-4C)烷氧基、硫代吗啉-(2-4C)烷氧基、1-氧代硫代吗啉-(2-4C)烷氧基或1,1-二氧代硫代吗啉-(2-4C)烷氧基，其中上述任何一个具有未连接到N或O原子的CH2(亚甲基)基的R1取代基可选择在该 基上具有一个羟基取代基；或其药学上可接受的盐；以及它们的制备方法、包含它们的制药组合物和利用该化合物的受体酪氨酸激酶抑制性质治疗增殖性疾病如癌症的用途。
• NOVEL COMBINATIONAL USE OF SULFONAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1859793A1

  公开（公告）日：2007-11-28

  The present invention relates to a pharmaceutical composition, a kit and a method for treating cancer, comprising a sulfonamide compound in combination with a substance having an EGF inhibitory activity.

  本发明涉及一种治疗癌症的药物组合物、试剂盒和方法，其中包括磺酰胺化合物与具有表皮生长因子抑制活性的物质的组合。
• PROCESS FOR PRODUCTION OF POLYESTER-CONTAINING FLEXIBLE POLYURETHANE FOAM, AND CATALYST COMPOSITION FOR USE IN THE PROCESS
  申请人：Tosoh Corporation

  公开号：EP2204394A1

  公开（公告）日：2010-07-07

  To provide a method for producing a low-odor polyester-type flexible polyurethane foam which is excellent in formability and free from scorch in the interior of the foam, and further discharges substantially no volatile amine compound from a product, in the production of a polyester-type flexible polyurethane foam, and to provide a catalyst composition to be used for the production method. A polyester-type flexible polyurethane foam is produced by a process which comprises reacting a polyester polyol with a polyisocyanate, in the presence of a catalyst composition containing one or more amine compounds selected from the group consisting of an amine compound represented by the following formula (1): in the above formula (1), R1 is a C1-6 linear or branched alkyl group, and each of R2, R3, R4 and R5 which are independent of one another, is a hydrogen atom or a C1-2 alkyl group, an amine compound represented by the following formula (2): in the above formula (2), R6 is a C2-6 linear or branched alkylene group, and an amine compound represented by the following formula (3): in the above formula (3), each of R7 and R8 which are independent of each other, is a C1-4 alkyl group, and R9 is a C3-5 linear or branched alkylene group; a blowing agent; and a surfactant.

  提供一种生产低气味聚酯型软质聚氨酯泡沫塑料的方法，该泡沫塑料具有良好的成型性，泡沫塑料内部无焦烧现象，而且在生产聚酯型软质聚氨酯泡沫塑料时，产品中基本上不排放挥发性胺化合物，并提供一种用于该生产方法的催化剂组合物。 聚酯型软质聚氨酯泡沫塑料的生产工艺包括：在催化剂组合物存在的情况下，使聚酯多元醇与多异氰酸酯反应，催化剂组合物含有一种或多种胺化合物，这些胺化合物选自由下式(1)所代表的胺化合物组成的组： 在上式（1）中，R1 是 C1-6 直链或支链烷基，R2、R3、R4 和 R5 中的每一个彼此独立，是氢原子或 C1-2 烷基、 下式(2)所代表的胺化合物： 在上式（2）中，R6 是 C2-6 直链或支链亚烷基，以及下式（3）代表的胺化合物： 在上式（3）中，相互独立的 R7 和 R8 均为 C1-4 烷基，R9 为 C3-5 直链或支链亚烷基；发泡剂；以及表面活性剂。
• Alkali cleaner
  申请人：Yamada Yasuhiro

  公开号：US20050245422A1

  公开（公告）日：2005-11-03

  An alkali cleaner is described, including an alkali component (A), a polyvalent alcohol (B) of 3 to 8 valent containing no nitrogen atom and having a Mn of 92-400, and an alcohol (C). The alcohol (C) includes at least one alcohol selected from the group consisting of a divalent alcohol (C1) containing no nitrogen atom and having a Mn of 62-250 and a monovalent alcohol (C2) containing no nitrogen atom and having a Mn of 32-500.

  所述碱清洁剂包括碱成分（A）、不含氮原子且 Mn 为 92-400 的 3-8 价多价醇（B）和醇（C）。醇 (C) 包括至少一种选自以下组别的醇：不含氮原子且 Mn 为 62-250 的二价醇 (C1) 和不含氮原子且 Mn 为 32-500 的一价醇 (C2)。
• QUINAZOLINE DERIVATIVES
  申请人：ZENECA LIMITED

  公开号：EP0823900A1

  公开（公告）日：1998-02-18