| 908250-53-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 908250-53-3
• 化学式: C₁₉H₂₃NO₆
• 分子量: 361.395
• InChiKey: MJLVGQAWDPUGIS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological activity of novel shikonin analogues

  摘要：

  A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1 alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.032
• 作为产物：
  描述：

  在 silver(II) oxide 、 硝酸 作用下， 以 水 、 丙酮 为溶剂， 以59%的产率得到
  参考文献：
  名称：

  Synthesis and biological activity of novel shikonin analogues

  摘要：

  A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1 alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.032