3-[1'-(2'-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one | 354993-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[1'-(2'-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one
• 英文别名: 2-[4-(Dimethylamino)phenyl]-3-[1-(2-hydroxyphenyl)ethylideneamino]-1,2-dihydroquinazolin-4-one
• CAS: 354993-54-7
• 化学式: C₂₄H₂₄N₄O₂
• 分子量: 400.48
• InChiKey: GIJORMGNWXIZBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  aluminium trinitrate 、 3-[1'-(2'-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one 以 水 、 乙腈 为溶剂， 生成 Al(3+)*3-[1'-(2'-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one
  参考文献：
  名称：

  An effective mutli-wavelength emissive aluminum ion fluorescence chemosensor based on 3-[1′-(2′-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one

  摘要：

  In the paper, a novel mutli-wavelength emissive aluminium ion chemosensor based on 3-[1'-(2'-hydroxy-alpha-methylbenzylidene-imino)]-2-(p-N,N-dimethyl aminophenyl)-1,2-dihydroquinazolin-4(3H)-one is designed and synthesized. According to the fluorescence behavior toward several metal ions, it shows high selectivity to Al3+ over other commonly coexistent metal ions (Na+, Mg2+, Co2+, Ni2+, Cu2+, Fe3+, Cr3+, Hg2+, Zn2+, Cd2+) in aqueous environment (pH 7.40). Meanwhile the binding constant between Al3+ and chemosensor achieves 3.92 x 10(6) M (1) in aqueous media. Moreover, according to the Job plot, 1: 1 stoichiometry between Al3+ and the sensor was deduced in aqueous media (pH 7.4). The good selectivity and sensitivity in aqueous media effectively enhance the application value of the chemosensor for Al3+. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.009
• 作为产物：
  描述：

  、 对二甲氨基苯甲醛 以 乙醇 为溶剂， 反应 1.0h， 以75%的产率得到3-[1'-(2'-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one
  参考文献：
  名称：

  An effective mutli-wavelength emissive aluminum ion fluorescence chemosensor based on 3-[1′-(2′-hydroxy-α-methylbenzylidene-imino)]-2-(p-N,N-dimethylaminophenyl)-1,2-dihydroquinazolin-4-(3H)-one

  摘要：

  In the paper, a novel mutli-wavelength emissive aluminium ion chemosensor based on 3-[1'-(2'-hydroxy-alpha-methylbenzylidene-imino)]-2-(p-N,N-dimethyl aminophenyl)-1,2-dihydroquinazolin-4(3H)-one is designed and synthesized. According to the fluorescence behavior toward several metal ions, it shows high selectivity to Al3+ over other commonly coexistent metal ions (Na+, Mg2+, Co2+, Ni2+, Cu2+, Fe3+, Cr3+, Hg2+, Zn2+, Cd2+) in aqueous environment (pH 7.40). Meanwhile the binding constant between Al3+ and chemosensor achieves 3.92 x 10(6) M (1) in aqueous media. Moreover, according to the Job plot, 1: 1 stoichiometry between Al3+ and the sensor was deduced in aqueous media (pH 7.4). The good selectivity and sensitivity in aqueous media effectively enhance the application value of the chemosensor for Al3+. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.009