5-(2-carboxyethyl)-3’,5’-di-O-TBDMS-2-deoxyuridine | 191849-07-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(2-carboxyethyl)-3’,5’-di-O-TBDMS-2-deoxyuridine
• CAS: 191849-07-7
• 化学式: C₂₄H₄₄N₂O₇Si₂
• 分子量: 528.794
• InChiKey: BWSKDSCJJRWBRJ-IPMKNSEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  35.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  119.85
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (+)-(S)-4,5,6,7-tetrahydro-8-(hexaethylene glycol)-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione 、 5-(2-carboxyethyl)-3’,5’-di-O-TBDMS-2-deoxyuridine 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 76.0h， 以46%的产率得到2-[2-[2-[2-[2-[2-[[(11S)-11-methyl-10-(3-methylbut-2-enyl)-2-sulfanylidene-1,3,10-triazatricyclo[6.4.1.04,13]trideca-4(13),5,7-trien-7-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 3-[1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]propanoate
  参考文献：
  名称：

  Bifunctional inhibition of HIV-1 reverse transcriptase: A first step in designing a bifunctional triphosphate

  摘要：

  The onset of resistance to approved anti-AIDS drugs by HIV necessitates the search for novel inhibitors of HIV-1 reverse transcriptase (RT). Developing single molecular agents concurrently occupying the nucleoside and nonnucleoside binding sites in RT is an intriguing idea but the proof of concept has so far been elusive. As a first step, we describe molecular modeling to guide focused chemical syntheses of conjugates having nucleoside (d4T) and nonnucleoside (TIBO) moieties tethered by a flexible polyethylene glycol (PEG) linker. A triphosphate of d4T-6PEG-TIBO conjugate was successfully synthesized that is recognized as a substrate by HIV-1 RT and incorporated into a double-stranded DNA. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.12.015