(1S,5S)-3-(tetrahydrofuran-3-ylcarbonyl)-3,6-diazabicyclo[3.2.1]octane | 1215170-00-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (1S,5S)-3-(tetrahydrofuran-3-ylcarbonyl)-3,6-diazabicyclo[3.2.1]octane
• 英文别名: [(1S,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]-(oxolan-3-yl)methanone
• CAS: 1215170-00-5
• 化学式: C₁₁H₁₈N₂O₂
• 分子量: 210.276
• InChiKey: FCAHOQKXTXPTMC-SMILAEQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF
  申请人：Strachan Jon-Paul

  公开号：US20110263629A1

  公开（公告）日：2011-10-27

  The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).

  本发明涉及结合并调节神经元尼古丁型乙酰胆碱受体活性的化合物，涉及制备这些化合物的方法，含有这些化合物的药物组合物，以及使用这些化合物治疗各种疾病和疾病的方法，包括与中枢神经系统（CNS）功能障碍相关的疾病。
• [EN] AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF<br/>[FR] AMIDES DE DIAZABICYCLOOCTANES ET LEURS UTILISATIONS
  申请人：TARGACEPT INC

  公开号：WO2010028033A1

  公开（公告）日：2010-03-11

  The present invention relates to compounds of the following formulae I and II that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). Formula (I ), Formula (Il)