2'-O-Methyluridine 5'-(α-thiotriphosphate) | 926632-30-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2'-O-Methyluridine 5'-(α-thiotriphosphate)
• CAS: 926632-30-6
• 化学式: C₁₀H₁₇N₂O₁₄P₃S
• 分子量: 514.237
• InChiKey: OSMHTCORMPAXLE-WOUHMYQASA-N

物化性质

• 密度：
  1.89±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-3-(4-tert-butyl-benzoyl)-1H-pyrimidine-2,4-dione 生成 2'-O-Methyluridine 5'-(α-thiotriphosphate)
  参考文献：
  名称：

  Novel solid phase synthesis of 2'-o-methylribonucleoside 5'-triphosphates and their α-thio analogues

  摘要：

  Simple, versatile and convenient syntheses of 2'-0-methyl-ribonucleoside 5'-triphosphates have been accomplished on controlled pore glass (CPG) in good yield (>60%) using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl phosphorochloridite). Moderate yields were obtained for the corresponding alpha-thiotri-phosphates.

  DOI：

  10.1016/s0040-4039(00)92072-0