7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-3,4-dihydronaphthalene | 945421-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-3,4-dihydronaphthalene
• 英文别名: [4-(6-methoxy-2-phenyl-1,2-dihydronaphthalen-1-yl)phenyl] 2,2-dimethylpropanoate
• CAS: 945421-08-9
• 化学式: C₂₈H₂₈O₃
• 分子量: 412.529
• InChiKey: KBNPTUPUBLMYQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-3,4-dihydronaphthalene 在 potassium tert-butylate 、 水 、 氯化铵 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以69%的产率得到4-(6-甲氧基-2-苯基-3,4-二氢萘并醛烯-1-基)苯酚
  参考文献：
  名称：

  EP1982981

  摘要：

  公开号：
• 作为产物：
  描述：

  2-iodo-7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-1,2,3,4-tetrahydronaphthalene 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 反应 0.25h， 以75%的产率得到7-methoxy-3-phenyl-4-(4-pivaloyloxyphenyl)-3,4-dihydronaphthalene
  参考文献：
  名称：

  EP1982981

  摘要：

  公开号：

文献信息

• Process for Production of Lasofoxifene or Analogue Thereof
  申请人：Shiina Isamu

  公开号：US20090012314A1

  公开（公告）日：2009-01-08

  Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue thereof, a compound represented by the formula (4) is used as an intermediate. The compound represented by the formula (4) can be produced using compounds represented by the formulae (1) to (3) as starting compounds by performing the coupling of the three components in one step.

  本发明公开了一种生产拉索福辛、纳福西汀或其类似物的新工艺，该工艺步骤较少，效率高，实用性优越。用于生产拉索福辛或其类似物的中间体化合物是由式（4）表示的化合物。可以通过在一步中耦合三个组分来使用由式（1）到（3）表示的化合物作为起始化合物，从而制备由式（4）表示的化合物。
• Dihydronaphthalene compound and use thereof
  申请人：Tokyo University of Science Educational Foundation Administrative Organization

  公开号：US08183235B2

  公开（公告）日：2012-05-22

  Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two —(CH2)l—N(R1) (R2) groups represent a same substituent; R1 and R2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R1 and R2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R3, R4 and R5 each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; l represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)

  本发明公开了一种化合物，其化学结构为二氢萘衍生物，化学式（I）如下，与拉索福辛和纳福西汀相比，该化合物的生产效率更高。该化合物可用作蛋白酶抑制剂和/或抗肿瘤剂。（在公式中，两个—（CH2）l—N（R1）（R2）基团代表同一取代基；R1和R2分别代表氢原子或相同或不同的烷基基团；或者，R1和R2可以结合在一起形成一个单环杂环，其中含有它们或另外与选择的一个或多个原子一起选择自氧原子、硫原子和氮原子的氮原子；R3、R4和R5各代表从氢原子、烷基基团、酰基基团、脂环基团、芳基基团、卤素原子、酰氧基团、氰基团和硝基团中选择的一个或多个取代基；l代表2-5的整数；n代表1-4的整数；m代表1-5的整数；q代表1-3的整数。）
• Process for production of lasofoxifene or analogue thereof
  申请人：Tokyo University of Science Educational Foundation Administrative Organization

  公开号：US08193394B2

  公开（公告）日：2012-06-05

  Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue thereof, a compound represented by the formula (4) is used as an intermediate. The compound represented by the formula (4) can be produced using compounds represented by the formulae (1) to (3) as starting compounds by performing the coupling of the three components in one step.

  本发明公开了一种新型的拉索福辛、纳福西定或其类似物的生产工艺，该工艺步骤少、效率高、实用性优越。在生产拉索福辛或其类似物时，使用化合物（4）表示的中间体。化合物（4）可以通过使用化合物（1）到（3）表示的起始化合物，在一步反应中耦合三个组分来制备。
• NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF
  申请人：Shiina Isamu

  公开号：US20100249400A1

  公开（公告）日：2010-09-30

  Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two —(CH 2 ) l —N(R 1 ) (R 2 ) groups represent a same substituent; R 1 and R 2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R 1 and R 2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R 3 , R 4 and R 5 each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; l represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)

  本发明涉及一种化合物，其化学结构为二氢萘类化合物，由公式（I）表示，与拉索福辛和纳福西丁相比，其生产效率更高。该化合物可用作蛋白酶体抑制剂和/或抗肿瘤剂。（在公式中，两个—（CH2）l—N（R1）（R2）基团表示相同的取代基；R1和R2分别表示氢原子或相同或不同的烷基基团；或者，R1和R2可以结合在一起形成一个单环杂环，其中含有氮原子或与氮原子一起选择的一个或多个原子，如氧原子、硫原子和氮原子；R3、R4和R5分别表示从氢原子、烷基基团、酰基基团、脂环基团、芳基基团、卤素原子、酰氧基团、氰基团和硝基团中选择的一个或多个取代基；l表示2-5的整数；n表示1-4的整数；m表示1-5的整数；q表示1-3的整数。）
• PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF
  申请人：Tokyo University of Science, Educational Foundation

  公开号：EP1982981A1

  公开（公告）日：2008-10-22

  Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue thereof, a compound represented by the formula (4) is used as an intermediate. The compound represented by the formula (4) can be produced using compounds represented by the formulae (1) to (3) as starting compounds by performing the coupling of the three components in one step.

  本发明公开了一种生产拉索昔芬、萘福昔定或其类似物的新工艺，该工艺减少了反应步骤，效率高，具有实际优势。生产拉索昔芬或其类似物时，使用式（4）代表的化合物作为中间体。以式（1）至（3）所代表的化合物为起始化合物，通过一步耦合三种组分，可以制得式（4）所代表的化合物。