ethyl 2-(pyridin-2-yl)imidazo[1,2-a]pyrimidine-3-carboxylate | 1431554-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]嘧啶
• 英文名称: ethyl 2-(pyridin-2-yl)imidazo[1,2-a]pyrimidine-3-carboxylate
• 英文别名: Ethyl 2-pyridin-2-ylimidazo[1,2-a]pyrimidine-3-carboxylate
• CAS: 1431554-37-8
• 化学式: C₁₄H₁₂N₄O₂
• 分子量: 268.275
• InChiKey: YAUDKJIWEBBHGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel Substituted Imidazopyrimidines as Gpbar1 Receptor Modulators
  申请人：Torrent Pharmaceuticals Limited.

  公开号：US20150126530A1

  公开（公告）日：2015-05-07

  The present invention relates to novel substituted imidazo[1,2-a]pyrimidine compounds of formula (I), their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further” relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals. (Formula I).

  本发明涉及一种新型的取代咪唑[1,2-a]嘧啶化合物（I）及其药用盐、其异构体、立体异构体、构象体、互变异构体、多晶型、水合物和溶剂合物。本发明还包括所述化合物的药用组合物和制备新化合物的方法。该发明还涉及上述化合物用于制备药物用作药品的用途。