(3S,5S)-3-hydroxy-5-methyl-7-oxa-8-cholesten-6-one | 1262676-52-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3S,5S)-3-hydroxy-5-methyl-7-oxa-8-cholesten-6-one
• 英文别名: (1R,3aR,5aS,7S,9aR,11aR)-7-hydroxy-5a,9a,11a-trimethyl-1-[(2R)-6-methylheptan-2-yl]-1,2,3,3a,6,7,8,9,10,11-decahydroindeno[4,5-c]isochromen-5-one
• CAS: 1262676-52-7
• 化学式: C₂₇H₄₄O₃
• 分子量: 416.645
• InChiKey: QLKXJUVQTOHODN-JZILLYPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• STEROL DERIVATIVE
  申请人：Uchida Kenji

  公开号：US20120172348A1

  公开（公告）日：2012-07-05

  The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; X a and X b are the same or different, and represent a bond or the like; R 1 , R 2 , R 3 , R 4 , R 7 and R 8 are the same or different, and represent a hydrogen atom or the like; R 5 and R 6 are the same or different, and represent a hydrogen atom or the like; R 9 represents a hydrogen atom or the like; R 10 and R 11 together represent a bond or the like; and R 12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.

  本发明提供了一种甾醇衍生物或其药学上可接受的盐，具有促进神经干细胞增殖的活性。即，本发明提供了一种由通式（I）表示的甾醇衍生物（其中，Y表示可选择的取代的低碳基或类似物；Xa和Xb相同或不同，表示键或类似物；R1、R2、R3、R4、R7和R8相同或不同，表示氢原子或类似物；R5和R6相同或不同，表示氢原子或类似物；R9表示氢原子或类似物；R10和R11一起表示键或类似物；R12表示氢原子或类似物）或其药学上可接受的盐。
• US8952003B2
  申请人：——

  公开号：US8952003B2

  公开（公告）日：2015-02-10