2-naphthyldibenzyl phosphate | 949887-41-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-naphthyldibenzyl phosphate
• 英文别名: dibenzyl naphthalen-2-yl phosphate；phosphoric acid dibenzyl ester-[2]naphthyl ester；Phosphorsaeure-dibenzylester-[2]naphthylester；Dibenzyl-(naphthyl-(2))-phosphat
• CAS: 949887-41-6
• 化学式: C₂₄H₂₁O₄P
• 分子量: 404.402
• InChiKey: WZSTUYXPHPOCAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  539.4±43.0 °C(Predicted)
• 密度：
  1.254±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-naphthyldibenzyl phosphate 在 甲醇 、 镍 作用下， 生成 2-萘基磷酸钠
  参考文献：
  名称：

  94.磷酸化研究。第一部分：氯膦酸二苄酯作为磷酸化剂

  摘要：

  DOI：

  10.1039/jr9450000382
• 作为产物：
  描述：

  亚磷酸二苄酯 在 四氯化碳 、 氯 、 甲苯 作用下， 生成 2-naphthyldibenzyl phosphate
  参考文献：
  名称：

  94.磷酸化研究。第一部分：氯膦酸二苄酯作为磷酸化剂

  摘要：

  DOI：

  10.1039/jr9450000382

文献信息

• Synthesis of Phosphate Esters by Using Diphenyl Ditelluride as Organocatalyst
  作者：Helen A. Goulart、Daniela R. Araujo、Lucas E. B. Iarocz、Bruna R. Pizzi、Thiago Barcellos、Márcio S. Silva、Gelson Perin

  DOI：10.1002/ejoc.202300021

  日期：——

  This work demonstrates an approach to prepare phosphate esters by a dehydrogenative phosphorylation reaction between functionalized naphthols and H-phosphonates using diphenyl ditelluride as an organocatalyst and sonochemistry as an alternative energy source. The method was also suitable to the use α-naphthol, β-naphthol, phenol and thiophenol.

  这项工作展示了一种通过功能化萘酚和H-膦酸酯之间的脱氢磷酸化反应制备磷酸酯的方法，使用二苯基二碲化物作为有机催化剂和声化学作为替代能源。该方法也适用于α-萘酚、β-萘酚、苯酚和苯硫酚。
• Catalytic Lewis acid phosphorylation with pyrophosphates
  作者：Owen S. Fenton、Emily E. Allen、Kyle P. Pedretty、Sean D. Till、Joseph E. Todaro、Bianca R. Sculimbrene

  DOI：10.1016/j.tet.2012.08.070

  日期：2012.11

  We report a method for the Lewis acid catalyzed phosphorylation of alcohols with pyrophosphates. Ti((OBu)-Bu-t)(4) was found to be the most effective catalyst in the phosphorylation of both primary and secondary alcohols with tetrabenzylpyrophosphate, providing conversions between 54% and >98% and isolated yields between 50% and 97%. Other pyrophosphates with orthogonal protecting groups were synthesized and screened to validate the generality of the approach. This study will describe how benzyl, methyl, ethyl, allyl, and o-nitrobenzyl pyrophosphates are all effective phosphorylating agents under Lewis acid catalysis. (C) 2012 Elsevier Ltd. All rights reserved.
• Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
  作者：Pierre Deprez、Eliane Mandine、Dominique Gofflo、Stéphane Meunier、Dominique Lesuisse

  DOI：10.1016/s0960-894x(02)00140-3

  日期：2002.5

  Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.