(1α,5α,6α)-6-[(2-tetrahydropyranyl)oxy]methyl-3-azabicyclo[3.1.0]hexane | 504437-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (1α,5α,6α)-6-[(2-tetrahydropyranyl)oxy]methyl-3-azabicyclo[3.1.0]hexane
• CAS: 504437-78-9
• 化学式: C₁₁H₁₉NO₂
• 分子量: 197.277
• InChiKey: FZXBHBGSMVGOKD-GYNUPAMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  14.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.49
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (1α,5α,6α)-6-[(2-tetrahydropyranyl)oxy]methyl-3-azabicyclo[3.1.0]hexane 、 3,4,5-三氟硝基苯 生成 3,5-difluoro-4-[(1α,5α,6α)-6-[(2-tetrahydropyranyl) oxy]methyl-3-azabicyclo[3.1.0]hexan-3-yl]nitrobenzene
  参考文献：
  名称：

  Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof

  摘要：

  含有含有双环[3.1.0]己烷基团的噁唑烷酮，对需氧菌和厌氧病原体具有有效作用，如多耐药葡萄球菌、链球菌和肠球菌、Bacteroides属、Clostridia属物种，以及酸快细菌如结核分枝杆菌和其他分枝杆菌物种。该化合物由结构式I表示：其对映体、二对映体或其药用可接受的盐或酯，其中变量R1、R2、R3、R4、R4a、A、Ar、HAr、n、r和s的定义如本文所述。

  公开号：

  US20030125367A1

文献信息

• Bicyclo[3.1.0]hexane containing oxazolidinone antibiotics and derivatives thereof
  申请人：Fukuda Yasumichi

  公开号：US20050203144A1

  公开（公告）日：2005-09-15

  Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof, and wherein the variables R 1 , R 2 , R 3 , R 4 , R 4a , A, Ar, HAr, n, r, and s are as defined herein.

  具有含有双环[3.1.0]己烷基团的噁唑烷酮，对多重耐药的葡萄球菌，链球菌和肠球菌，Bacteroides spp.，Clostridia spp.物种以及酸性快速生物如结核分枝杆菌和其他分枝杆菌物种具有有效抗菌作用。该化合物由结构式I表示：其对映异构体，顺反异构体或其药学上可接受的盐或酯，其中变量R1，R2，R3，R4，R4a，A，Ar，HAr，n，r和s如此定义。
• EP1385834A1
  申请人：——

  公开号：EP1385834A1

  公开（公告）日：2004-02-04
• BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1385834B1

  公开（公告）日：2005-09-14
• US6897230B2
  申请人：——

  公开号：US6897230B2

  公开（公告）日：2005-05-24
• [EN] BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF<br/>[FR] ANTIBIOTIQUES OXAZOLIDINONE CONTENANT DU BICYCLO[3.1.0] HEXANE ET DERIVES DE CES DERNIERS
  申请人：MERCK & CO INC

  公开号：WO2003027083A1

  公开（公告）日：2003-04-03

  Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, Streptococci and enterococci, Bacteroides spp., Clostridia spp.species, as well as acid-fast organisms such as MYCOBACTERIUM TUBERCULOSISand other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof, and wherein the variables R1, R2, R3, R4a, A, Ar, HAr, n, r, and s are as defined herein.