1-((1-(2,2-difluoroethyl)piperidin-3-yl)methyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine | 1346162-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 1-((1-(2,2-difluoroethyl)piperidin-3-yl)methyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
• 英文别名: 1-[[1-(2,2-difluoroethyl)piperidin-3-yl]methyl]-N-(1-methylpyrazol-4-yl)pyrazolo[3,4-d]pyrimidin-6-amine
• CAS: 1346162-19-3
• 化学式: C₁₇H₂₂F₂N₈
• 分子量: 376.412
• InChiKey: MOSPYCWDSBWIIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] PYRAZOLE COMPOUNDS AS JAK INHIBITORS<br/>[FR] COMPOSÉS DE PYRAZOLE COMME INHIBITEURS DE JAK
  申请人：CELLZOME LTD

  公开号：WO2011134831A1

  公开（公告）日：2011-11-03

  The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  本发明涉及公式(I)的化合物，其中R1、R2、R1a、R1b的含义如描述和权利要求中所述。所述化合物可用作JAK抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导的疾病。本发明还涉及包括所述化合物的药物组合物，以及制备此类化合物和用作药物的用途。
• PYRAZOLE COMPOUNDS AS JAK INHIBITORS
  申请人：Harrison Richard John

  公开号：US20130131043A1

  公开（公告）日：2013-05-23

  The invention relates to compounds of formula (I) wherein R 1 , R 2 , R 1a , R 1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

  该发明涉及式（I）化合物，其中R1，R2，R1a，R1b的含义如说明书和权利要求书中所述。所述化合物可用作JAK抑制剂，用于治疗或预防免疫、炎症、自身免疫、过敏性疾病和免疫介导性疾病。该发明还涉及包括所述化合物的制药组合物，制备这种化合物以及用作药物的使用。