4,7-diamino-2-methyl-isoindole-1,3-dione | 2868-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4,7-diamino-2-methyl-isoindole-1,3-dione
• 英文别名: 3,6-Diamino-N-methylphthalimid；3,6-Diamino-N-methylphthalimide；4,7-diamino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione；4,7-diamino-2-methylisoindole-1,3-dione
• CAS: 2868-12-4
• 化学式: C₉H₉N₃O₂
• mdl: MFCD20690557
• 分子量: 191.189
• InChiKey: NLYHOVUYOJUULF-UHFFFAOYSA-N

物化性质

• 沸点：
  417.1±35.0 °C(Predicted)
• 密度：
  1.503±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  89.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• S6K1 PROTEIN KINASE INHIBITORS AS CANCER THERAPEUTICS
  申请人：Xavier University of Louisiana

  公开号：US20210323919A1

  公开（公告）日：2021-10-21

  The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.

  本公开涉及作为蛋白激酶抑制剂的化合物，特别是RPS6K1以及其合成。此外，本公开教导了利用这些化合物治疗增殖性疾病，包括癌症，特别是乳腺癌，尤其是ER+和/或HER2+乳腺癌，前列腺癌，肺癌和转移性癌症。
• SMALL MOLECULE INHIBITORS OF THE BFRB:BFD INTERACTION
  申请人：UNIVERSITY OF KANSAS

  公开号：US20220031661A1

  公开（公告）日：2022-02-03

  The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.