2-{4-(3,5-dimethoxybenzyl)-1-[N-(4-methoxybenzenesufonyl)-N-(4-methoxyphenethyl)-aminoacetyl]-6-(S)-methyl-5-oxo-piperazin-2-yl}-N-hydroxy-acetamide | 362021-65-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 2-{4-(3,5-dimethoxybenzyl)-1-[N-(4-methoxybenzenesufonyl)-N-(4-methoxyphenethyl)-aminoacetyl]-6-(S)-methyl-5-oxo-piperazin-2-yl}-N-hydroxy-acetamide
• 英文别名: 2-[(6S)-4-[(3,5-dimethoxyphenyl)methyl]-1-[2-[2-(4-methoxyphenyl)ethyl-(4-methoxyphenyl)sulfonylamino]acetyl]-6-methyl-5-oxopiperazin-2-yl]-N-hydroxyacetamide
• CAS: 362021-65-6
• 化学式: C₃₄H₄₂N₄O₁₀S
• 分子量: 698.794
• InChiKey: FRYWQRNQRQZXBL-ZZHFZYNASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  49
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  173
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• US6294539B1
  申请人：——

  公开号：US6294539B1

  公开（公告）日：2001-09-25
• [EN] HETEROCYCLIC HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS<br/>[FR] DERIVES D'ACIDE HETEROCYCLIQUE HYDROXAMIQUE COMME INHIBITEURS DES MMP
  申请人：ADVANCED SYNTECH LLC A KENUCKY

  公开号：WO2002071844A1

  公开（公告）日：2002-09-19

  Novel MMP inhibitor compositions comprising heterocyclic hydroxamic acid derivatives of formula: (I) These compounds are useful in the treatment of diseases and conditions in which matrix metalloproteinases are involved, such as cancer, arthritis, tumor metastasis and multiple sclerosis.