7-(2-C-methyl-5-triphospho-β-D-ribofuranosyl)-5-pyrimidin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | 1214752-12-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 7-(2-C-methyl-5-triphospho-β-D-ribofuranosyl)-5-pyrimidin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 英文别名: [[(2R,3R,4R,5R)-5-(4-amino-5-pyrimidin-2-ylpyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 1214752-12-1
• 化学式: C₁₆H₂₁N₆O₁₃P₃
• 分子量: 598.296
• InChiKey: BZWMWQFIWRMQMN-JEGMJTAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  292
• 氢给体数：
  7
• 氢受体数：
  18

文献信息

• NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES
  申请人：Avolio Salvatore

  公开号：US20110306573A1

  公开（公告）日：2011-12-15

  Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; wherein R 1 ; R 2 ; R 3 ; Q 1 and Q 2 are as defined herein, processes for their preparation; pharmaceutical compositions containing them and their use in medicine, in particular the treatment or prevention of HCV infections, are disclosed.

  结构式(I)的化合物及其药用盐；其中R1、R2、R3、Q1和Q2如本文所定义，其制备方法；含有它们的药物组合物以及它们在医学中的应用，特别是用于治疗或预防HCV感染，已被披露。
• [EN] NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES<br/>[FR] DÉRIVÉS DE NUCLÉOSIDE EN TANT QU'INHIBITEURS DE POLYMÉRASES VIRALES
  申请人：ANGELETTI P IST RICHERCHE BIO

  公开号：WO2010026153A1

  公开（公告）日：2010-03-11

  Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; wherein R1; R2; R3;Q1and Q2 are as defined herein, processes for their preparation; pharmaceutical compositions containing them and their use in medicine, in particular the treatment or prevention of HCV infections, are disclosed.