4-chloro-1-pyrimidin-2-yl-1H-indole-3-carboxylic acid [2-(4-chloro-phenyl)-pentyl]-amide | 1119282-16-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-chloro-1-pyrimidin-2-yl-1H-indole-3-carboxylic acid [2-(4-chloro-phenyl)-pentyl]-amide
• 英文别名: 4-chloro-N-[2-(4-chlorophenyl)pentyl]-1-pyrimidin-2-ylindole-3-carboxamide
• CAS: 1119282-16-4
• 化学式: C₂₄H₂₂Cl₂N₄O
• 分子量: 453.371
• InChiKey: FSSJSUBFNKMDTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Heteroaryl Amide Analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20120190680A1

  公开（公告）日：2012-07-26

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X 7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

  本发明揭示了公式Ia和/或Ib的杂环酰胺类似物的化合物、制药组合物和使用方法：在某些实施例中，杂环酰胺类似物是多巴胺受体的激动剂和/或配体，可用于治疗对P2X7受体调节有反应的疾病，例如疼痛、炎症、神经或神经退行性疾病、心血管疾病、眼部疾病或免疫系统疾病等。
• [EN] HETEROARYL AMIDE ANALOGUES<br/>[FR] ANALOGUES D'HÉTÉROARYLAMIDE
  申请人：LUNDBECK & CO AS H

  公开号：WO2009108551A2

  公开（公告）日：2009-09-03

  Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib. In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.