2,4,6-trichloro-N-[5-(3-chlorothien-2-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide | 531550-25-1

分子结构分类

有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩

中文名称

——

中文别名

——

英文名称

2,4,6-trichloro-N-[5-(3-chlorothien-2-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide

英文别名

2,4,6-trichloro-N-[5-(3-chlorothiophen-2-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide

2,4,6-trichloro-N-[5-(3-chlorothien-2-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide化学式

CAS

531550-25-1

化学式

C₁₂H₅Cl₄N₃O₂S₃

mdl

——

分子量

461.201

InChiKey

UKMMQSXJOVWOQI-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

5.1
重原子数：

24
可旋转键数：

4
环数：

3.0
sp3杂化的碳原子比例：

0.0
拓扑面积：

137
氢给体数：

1
氢受体数：

7

文献信息

Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

申请人：——

公开号：US20030130258A1

公开（公告）日：2003-07-10

The present invention relates to compounds with the formula (I) 1 and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-&bgr;-hydroxysteroid dehydrogenase type 1 enzyme.

本发明涉及式 (I) 的化合物 1 以及包含这些化合物的药物组合物，还涉及这些化合物在医药中的用途和制备对人类 11-&bgr;- 羟基类固醇脱氢酶 1 型酶起作用的药物。
INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1

申请人：BIOVITRUM AB

公开号：EP1461327A1

公开（公告）日：2004-09-29
US7074788B2

申请人：——

公开号：US7074788B2

公开（公告）日：2006-07-11
[EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE LA 11-BETA-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1

申请人：BIOVITRUM AB

公开号：WO2003044000A1

公开（公告）日：2003-05-30

The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.
[EN] USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING<br/>[FR] UTILISATION D'UN INHIBITEUR DE COMPOSE DE TYPE 1 11-B-HYDROXYSTEROIDE DESHYDROGENASE TYPE 1 DESTINE A FACILITER LA CICATRISATION D'UNE PLAIE

申请人：BIOVITRUM AB

公开号：WO2004113310A1

公开（公告）日：2004-12-29

The invention relates to a method for promoting wound healing, said method comprising administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-ß-hydroxysteroid dehydrogenase type 1 wherein the said l lß-HSD1 inhibitor has the formula (I) wherein T, R1, A1 and A2 are as defined in the specification. These compounds may also be used in the manufacture of a medicament for promoting wound healing.

同类化合物

锡烷,1,1'-(3,3'-二烷基[2,2'-二噻吩]-5,5'-二基)双[1,1,1-三甲基- 试剂5,10-Bis((5-octylthiophen-2-yl)dithieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene-2,7-diyl)bis(trimethylstannane) 试剂2,2'-Thieno[3,2-b]thiophene-2,5-diylbis-3-thiophenecarboxylicacid 试剂1,1'-[4,8-Bis[5-(dodecylthio)-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]bis[1,1,1-trimethylstannane] 苯并[b]噻吩,3-(2-噻嗯基)- 聚（3-己基噻吩-2,5-二基）（区域规则）甲基[2,3'-联噻吩]-5-羧酸甲酯牛蒡子醇 B 噻吩并[3,4-B]吡嗪,5,7-二-2-噻吩- 噻吩[3,4-B]吡嗪,5,7-双(5-溴-2-噻吩)- 十四氟-Alpha-六噻吩三丁基(5''-己基-[2,2':5',2''-三联噻吩]-5-基)锡 α-四联噻吩 α-六噻吩 α-五联噻吩 α-七噻吩 α,ω-二己基四噻吩 5,5′-双(3-己基-2-噻吩基)-2,2′-联噻吩 α,ω-二己基六联噻吩 Α-八噻吩 alpha-三联噻吩甲醇 alpha-三联噻吩 [3,3-Bi噻吩]-2,2-二羧醛 [2,2’]-双噻吩-5,5‘-二甲醛 [2,2':5',2''-三联噻吩]-5,5''-二基双[三甲基硅烷] [2,2'-联噻吩]-5-甲醇,5'-(1-丙炔-1-基)- [2,2'-联噻吩]-5-甲酸甲酯 [2,2'-联噻吩]-5-乙酸,a-羟基-5'-(1-炔丙基)-(9CI) IN1538,4,6-双(4-癸基噻吩基)-噻吩并[3,4-C][1,2,5]噻二唑(S) C-[2,2-二硫代苯-5-基甲基]胺 6,6,12,12-四(4-己基苯基)-6,12-二氢二噻吩并[2,3-D:2',3'-D']-S-苯并二茚并[1,2-B:5,6-B']二噻吩-2,8-双三甲基锡 5’-己基-2,2’-联噻吩-5-硼酸频哪醇酯 5-辛基-1,3-二（噻吩-2-基）-4H-噻吩并[3,4-c]吡咯-4,6（5H）-二酮 5-苯基-2,2'-联噻吩 5-溴5'-辛基-2,2'-联噻吩 5-溴-5′-己基-2,2′-联噻吩 5-溴-5'-甲酰基-2,2':5'2'-三噻吩 5-溴-3,3'-二己基-2,2'-联噻吩 5-溴-3'-癸基-2,2':5',2''-三联噻吩 5-溴-2,2-双噻吩 5-溴-2,2'-联噻吩-5'-甲醛 5-氯-5'-苯基-2,2'-联噻吩 5-氯-2,2'-联噻吩 5-正辛基-2,2'-并噻吩 5-己基-5'-乙烯基-2,2'-联噻吩 5-己基-2,2-二噻吩 5-全氟己基-5'-溴-2,2'-二噻吩 5-全氟己基-2,2′-联噻吩 5-乙酰基-2,2-噻吩基 5-乙氧基-2,2'-联噻吩 5-丙酰基-2,2-二噻吩

2,4,6-trichloro-N-[5-(3-chlorothien-2-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide | 531550-25-1

分子结构分类

计算性质

文献信息

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