1,2-diaminocyclohexane diethylmalonate platinum(II) complex | 131723-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 1,2-diaminocyclohexane diethylmalonate platinum(II) complex
• CAS: 131723-99-4；131724-00-0；131723-98-3；131655-84-0
• 化学式: C₁₃H₂₄N₂O₄Pt
• 分子量: 467.425
• InChiKey: KFPBRDSNXVWSRS-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  顺式-(R,S)-1,2-二氨基环己烷铂硫酸盐 、 barium diethylmalonate 以 水 为溶剂， 生成 1,2-diaminocyclohexane diethylmalonate platinum(II) complex
  参考文献：
  名称：

  Chemical and biological characterization of a series of water soluble 1,2-diaminocyclohexane platinum(II) complexes

  摘要：

  A series of water soluble 1,2-diaminocyclohexane platinum(II) complexes have been synthesized and analyzed for their mode of ligand coordination and biological activity. Preliminary in vitro and in vivo screening tests indicate that these complexes have excellent antitumor activity and are not cross-resistant with DDP. These results suggest that this series of platinum complexes warrant further study for eventual introduction into clinical studies.

  DOI：

  10.1016/s0020-1693(00)85890-9