4,4-(哌嗪-1,4-二基)双(丁烷-1-磺酸) | 16045-14-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4,4-(哌嗪-1,4-二基)双(丁烷-1-磺酸)
• 英文名称: 1,4-bis(4-sulfobutyl)piperazinium
• 英文别名: 4,4'-piperazine-1,4-diyl-bis-butane-1-sulfonic acid；1,4-Bis-<4-sulfo-butyl>-piperazin；4,4'-(Piperazine-1,4-diyl)bis(butane-1-sulfonic acid)；4-[4-(4-sulfobutyl)piperazin-1-yl]butane-1-sulfonic acid
• CAS: 16045-14-0
• 化学式: C₁₂H₂₆N₂O₆S₂
• 分子量: 358.48
• InChiKey: OBCXLYATNJKYMT-UHFFFAOYSA-N

物化性质

• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 海关编码：
  2933599090

制备方法与用途

PIPBS 用于作为研究中的化合物。

反应信息

• 作为反应物：
  描述：

  4,4-(哌嗪-1,4-二基)双(丁烷-1-磺酸) 在 磷酸 作用下， 以 水 为溶剂， 反应 2.0h， 生成 1,4-bis(4-sulfobutyl)piperazinium bis(hydrogenphosphate)
  参考文献：
  名称：

  Convenient synthesis and application of novel bi-SO3H-functionalized ionic liquids based on piperazinium

  摘要：

  In this article, series of novel bi-SO3H-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammett method had been used to determine the acidity order of these ionic liquids, and the acidities of bi-SO3H-functionalized Its were stronger than that of traditional single-SO3H-functionalized ILs. Their catalytic activities in the synthesis of N-(3-phenyl)-3-oxo-1-(phenylpropyl)acetamide were investigated and they were consistent with their acidities. (C) 2012 Li Yi Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.06.043
• 作为产物：
  描述：

  哌嗪 、 1,4-丁磺酸内酯 以 水 为溶剂， 反应 0.08h， 生成 4,4-(哌嗪-1,4-二基)双(丁烷-1-磺酸)
  参考文献：
  名称：

  Convenient synthesis and application of novel bi-SO3H-functionalized ionic liquids based on piperazinium

  摘要：

  In this article, series of novel bi-SO3H-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammett method had been used to determine the acidity order of these ionic liquids, and the acidities of bi-SO3H-functionalized Its were stronger than that of traditional single-SO3H-functionalized ILs. Their catalytic activities in the synthesis of N-(3-phenyl)-3-oxo-1-(phenylpropyl)acetamide were investigated and they were consistent with their acidities. (C) 2012 Li Yi Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.06.043

文献信息

• METAL-ORGANIC FRAMEWORK PHASE AND CRYSTALLITE SHAPE CONTROL
  申请人：The Regents of the University of California

  公开号：US20200101439A1

  公开（公告）日：2020-04-02

  Methods of synthesizing crystalline metal-organic frameworks (MOFs) comprising polytopic organic linkers and cations, where each linker is connected to two or more cations, are provided. In the disclosed methods, the linkers are reacted with a compound of formula M n X m , where M is cationic Be, Mg, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Rh, Pd, Cd, or Hf, X is anionic, n and m are integers. The reacting is buffered by a buffer devoid of metal coordinating functionality when the pKa of the anion is below a threshold related to the lowest pKa of the linker. The reacting is optionally not buffered when the pKa of the anion is at or above this threshold. The disclosed methods lead to product phase MOF in which crystal growth is controlled leading to control over molecular diffusion.

  提供了一种合成包含多面体有机连接物和阳离子的结晶金属-有机框架（MOFs）的方法，其中每个连接物连接到两个或更多的阳离子。在所公开的方法中，连接物与式为MnXm的化合物反应，其中M为阳离子Be、Mg、Ca、Ti、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、Zr、Nb、Mo、Ru、Rh、Pd、Cd或Hf，X为阴离子，n和m为整数。当阴离子的pKa低于与连接物最低pKa相关的阈值时，反应由不具有金属配位功能的缓冲剂缓冲。当阴离子的pKa在或高于此阈值时，反应可以选择不缓冲。所公开的方法导致产物相MOF，其中晶体生长受控制，从而控制分子扩散。
• PRANOPROFEN EYEDROPS CONTAINING ORGANIC AMINE
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP0824916A1

  公开（公告）日：1998-02-25

  The present ophthalmic solution is a pranoprofen ophthalmic solution containing an organic amine. A preferred ophthalmic solution is a 0.01 to 0.5% pranoprofen ophthalmic solution containing 0.1 to 5.0% of the organic amine. The concentration of the organic amine is more preferably 0.5 to 2.5%. A preferred example of the organic amine is tromethamine or 4-(2-hydroxyethyl)-1-(2-sulfoethyl)piperazine. Optionally, 0.002 to 0.01% benzalkonium chloride is added thereto as a preserative. According to the present invention, there can be provided an ophthalmic solution having pranoprofen as an active ingredient, which has no change in composition, excellent stability and little irritation to eyes.

  本眼药水是一种含有有机胺的普拉洛芬眼药水。优选的眼用溶液是含有 0.1 至 5.0%有机胺的 0.01 至 0.5%普拉洛芬眼用溶液。有机胺的浓度更优选为 0.5%至 2.5%。有机胺的一个优选例子是曲美他敏或 4-(2-羟乙基)-1-(2-磺乙基)哌嗪。可选择添加 0.002-0.01% 的苯扎氯铵作为防腐剂。 根据本发明，可以提供一种以普拉洛芬为有效成分的眼科溶液，该溶液成分不变，稳定性好，对眼睛刺激小。
• Novel bi-SO3H-functionalized ionic liquids based on piperazinium: Highly efficient and recyclable catalysts for the synthesis of β-acetamido ketones
  作者：Yuanyuan Wang、Junlong Zhou、Kun Liu、Liyi Dai

  DOI：10.1016/j.molcata.2012.09.023

  日期：2013.1

  A series of novel bi-SO3H-functionalized ionic liquids were synthesized and acted as catalysts for the synthesis of beta-acetamido ketones. Compared with traditional single-SO3H-functionalized ionic liquids, less amount of catalysts, higher yields and shorter reaction time are the key features of this methodology. Hammett function values and the minimum-energy geometries of bi-SO3H-functionalized ILs were calculated and the results revealed that the acidities and catalytic activities of ILs in synthesis of beta-acetamido ketones were influenced by their structures. The IL[(PS)(2)pi][OTf](2) with the shortest H-O bond distance had the strongest acidity and the highest catalytic activity. (c) 2012 Elsevier B.V. All rights reserved.
• ELEKTROCHROME FORMULIERUNG, HERSTELLUNGSVERFAHREN DAZU UND ELEKTROCHROMES ORGANISCHES BAUELEMENT
  申请人：Siemens Aktiengesellschaft

  公开号：EP2435531B1

  公开（公告）日：2013-10-30
• US6281224B1
  申请人：——

  公开号：US6281224B1

  公开（公告）日：2001-08-28