5-(2-hydroxy-4-methyl-3,5-dinitro-phenyl)-pyridazin-3(2H)-one | 1321900-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-(2-hydroxy-4-methyl-3,5-dinitro-phenyl)-pyridazin-3(2H)-one
• 英文别名: 4-(2-hydroxy-4-methyl-3,5-dinitrophenyl)-1H-pyridazin-6-one
• CAS: 1321900-60-0
• 化学式: C₁₁H₈N₄O₆
• 分子量: 292.208
• InChiKey: VLZMXHMMSDTOOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  153
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-Bromomethyl-7-methyl-6,8-dinitrocoumarin 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以65%的产率得到5-(2-hydroxy-4-methyl-3,5-dinitro-phenyl)-pyridazin-3(2H)-one
  参考文献：
  名称：

  Novel One-Pot Synthesis for 2,5-Diaryl and 5-Aryl-pyridazin-3(2H)-ones

  摘要：

  A novel method for the synthesis of 2-phenyl-5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones and 5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones has been found during the reaction of 4-bromomethylcoumarins with phenylhydrazine and hydrazinehydrate, respectively, under controlled alkaline conditions.

  DOI：

  10.1080/00397911.2010.515330

文献信息

• Novel One-Pot Synthesis for 2,5-Diaryl and 5-Aryl-pyridazin-3(<i>2H</i>)-ones
  作者：Mahantesha Basanagouda、Manohar V. Kulkarni

  DOI：10.1080/00397911.2010.515330

  日期：2011.9.1

  A novel method for the synthesis of 2-phenyl-5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones and 5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones has been found during the reaction of 4-bromomethylcoumarins with phenylhydrazine and hydrazinehydrate, respectively, under controlled alkaline conditions.