3,3'-di(2-thiophenyl)-2,2'-dihydroxy-1,1'-binaphthyl | 1352522-53-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,3'-di(2-thiophenyl)-2,2'-dihydroxy-1,1'-binaphthyl
• 英文别名: 1-(2-Hydroxy-3-thiophen-2-ylnaphthalen-1-yl)-3-thiophen-2-ylnaphthalen-2-ol
• CAS: 1352522-53-2
• 化学式: C₂₈H₁₈O₂S₂
• 分子量: 450.582
• InChiKey: GOSHESMEDLJZKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'-di(2-thiophenyl)-2,2'-dihydroxy-1,1'-binaphthyl 在 三氯化磷 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Synthesis of modified binol-phosphoramidites

  摘要：

  A number of chiral phosphoramidite ligands containing electronically different N-heterocycles at the 3,3'-positions of the binol scaffold were synthesized. The nucleophilicity of the pendant heterocycles correlated with the propensity of the P(III) centre to undergo aerobic oxidation to P(V). Due to an unexpected Staudinger-type reaction between the product phosphoramidites, the order in which the individual synthetic transformations were conducted was found to be important. The synthesis of a phosphoramidite ligand containing flanking groups at the 3,3'-positions of the binol scaffold in addition to a stereogenic phosphorus atom was also undertaken. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.020
• 作为产物：
  描述：

  rac-2,2'-bis-(methoxymethoxy)-1,1'-binaphthalene 在 盐酸 、 四(三苯基膦)钯 、 正丁基锂 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.25h， 生成 3,3'-di(2-thiophenyl)-2,2'-dihydroxy-1,1'-binaphthyl
  参考文献：
  名称：

  Synthesis of modified binol-phosphoramidites

  摘要：

  A number of chiral phosphoramidite ligands containing electronically different N-heterocycles at the 3,3'-positions of the binol scaffold were synthesized. The nucleophilicity of the pendant heterocycles correlated with the propensity of the P(III) centre to undergo aerobic oxidation to P(V). Due to an unexpected Staudinger-type reaction between the product phosphoramidites, the order in which the individual synthetic transformations were conducted was found to be important. The synthesis of a phosphoramidite ligand containing flanking groups at the 3,3'-positions of the binol scaffold in addition to a stereogenic phosphorus atom was also undertaken. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.11.020

文献信息

• [EN] NOVEL PROCESSES FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS USING HYDROGEN BONDING CATALYSTS<br/>[FR] NOUVEAUX PROCÉDÉS DE PRODUCTION DE COMPOSÉS DE QUINAZOLINE SUBSTITUÉS À L'AIDE DE CATALYSEURS DE LIAISON HYDROGÈNE
  申请人：MERCK SHARP & DOHME

  公开号：WO2017091453A1

  公开（公告）日：2017-06-01

  Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.

  本文披露了一种使用氢键催化剂制备式（I）取代喹唑啉化合物的新工艺。
• Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10392353B2

  公开（公告）日：2019-08-27

  Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.

  本文公开了一种使用氢键催化剂制备式 (I) 取代喹唑啉化合物的新工艺。