4-Dimethylamino-2-methyl-tetrahydro-pyran | 90226-96-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 4-Dimethylamino-2-methyl-tetrahydro-pyran
• 英文别名: dimethyl-(2-methyl-tetrahydro-pyran-4-yl)-amine；N,N,2-trimethyloxan-4-amine
• CAS: 90226-96-3
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: VFRYZEQOSAROIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY
  申请人：GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

  公开号：EP1835921B1

  公开（公告）日：2010-08-18
• [EN] IMPROVED METHODS, KITS, COMPOSITIONS AND DOSING REGIMENS FOR THE USE OF HETEROCYCLIC INHIBITORS OF ERK1 AND ERK2<br/>[FR] MÉTHODES, KITS, COMPOSITIONS ET SCHÉMAS POSOLOGIQUES AMÉLIORÉS DESTINÉS À L'UTILISATION D'INHIBITEURS HÉTÉROCYCLIQUES D'ERK1 ET D'ERK2
  申请人：ASAN BIOSCIENCES LLC

  公开号：WO2021086726A1

  公开（公告）日：2021-05-06

  The present application provides improved compositions, methods, kits and dosing regimens for the use of heterocyclic compounds and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, or stereoisomers thereof. These compositions, methods, kits and dosing regimens are useful for modulating ERK1/2. By administering to a subject in need a therapeutically effective amount of one or more of the compounds of Formulae (I-III) or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, or stereoisomer thereof, or compositions of these, wherein X, Y, Z, J, M, and R1 to R8 are defined herein, these compounds and methods are effective in treating conditions associated with dysregulation of the RAS/RAF/MEK/ERK pathway or which are treatable by inhibiting Erk 1/2. A variety of conditions can be treated using these compounds and methods and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer.