(E)-2-(2-chlorostyryl)benzothiazole | 141838-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (E)-2-(2-chlorostyryl)benzothiazole
• 英文别名: 2-(2-chloro-styryl)-benzothiazole；2-[2-(2-chlorophenyl)ethenyl]benzothiazole；2-[(E)-2-(2-chlorophenyl)ethenyl]-1,3-benzothiazole
• CAS: 141838-78-0
• 化学式: C₁₅H₁₀ClNS
• 分子量: 271.77
• InChiKey: HTEKLEOBQXASPX-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium tetrachloroplatinate(II) 、 (E)-2-(2-chlorostyryl)benzothiazole 以 四氢呋喃 、 乙醇 、 水 为溶剂， 以12%的产率得到cis-dichlorobis{(E)-2-(2'-chlorostyryl)benzothiazole}platinum(II)
  参考文献：
  名称：

  Synthesis and characterization of new platinum(II) complexes containing thiazole and imidazole donors III. Dichlorobis(styrylbenzazole)platinum(II) complexes

  摘要：

  Platinum(II) complexes of the type cis-[Pt(L)2Cl2], where L is a styrylbenzazole, have been prepared. The benzazoles included derivatives of imidazole, thiazole and oxazole. The ligands and the complexes were characterized by their melting points, elemental analyses, NMR, UV-Vis and IR spectra. The benzazole ligands are all coordinated to the Pt through N. The assignment of cis geometry for the complexes was based on the method of synthesis, comparison with a styrylbenzazole complex of known geometry, and far-IR spectral data.

  DOI：

  10.1016/s0020-1693(00)80339-4
• 作为产物：
  描述：

  2-甲基苯并噻唑 、 2-氯苯甲醛 、 苄基三乙基氯化铵 以75%的产率得到
  参考文献：
  名称：

  LOKHANDE S. B.; RANGNEKAR D. W., INDIAN J. CHEM., 25,(1986) N 5, 485-488

  摘要：

  DOI：

文献信息

• FLUORESCENT CELLULAR MARKERS
  申请人：Zayas Beatriz

  公开号：US20100256378A1

  公开（公告）日：2010-10-07

  A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38(7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrobenzothiazolo[3,2-a]quinolinium chloride), ABQ-38(3-amino-7-ethylbenzimidazo[3,2-a]quinolinium chloride), and ABQ-95(3-amino-2-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride) wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage and caspases 3 and 7 activation, cellular organelles binding and damage, and a marker due to the auto-fluorescent properties.

  一种合成苯并咔唑[3,2-a]喹啉盐酸盐的方法，包括引入氨基取代基和硝基取代基，从而得到四种化合物，分别为NBQ-38（7-乙基-3-硝基苯并咪唑[3,2-a]喹啉盐酸盐），NBQ-95（2-氯-10-甲基-3-硝基苯并噻唑[3,2-a]喹啉盐酸盐），ABQ-38（3-氨基-7-乙基苯并咪唑[3,2-a]喹啉盐酸盐）和ABQ-95（3-氨基-2-氯-10-甲基苯并噻唑[3,2-a]喹啉盐酸盐）。该方法提高了化合物的生物活性。这些化合物进一步用于细胞内结合、通过线粒体损伤和caspases 3和7激活介导的凋亡激活对恶性细胞的细胞毒性、细胞器结合和损伤以及由于自荧光特性而产生的标记。
• Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein
  申请人：Kudo Yukitsuka

  公开号：US20050260126A1

  公开（公告）日：2005-11-24

  A compound, which is used for the diagnosis and the prophylaxis/treatment of diseases in which prion protein is accumulated, or specific staining of abnormal prion protein in samples, represented by the formula (I) or (II): or a salt or solvate thereof.

  一种化合物，用于诊断和预防/治疗朊病毒蛋白蓄积的疾病，或特异性染色样本中的异常朊病毒蛋白，由式（I）或（II）表示： 或其盐或溶解物。
• ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS
  申请人：SIMON FRASER UNIVERSITY

  公开号：US20170216252A1

  公开（公告）日：2017-08-03

  Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial agents in therapeutic and/or non-therapeutic contexts.
• US7329682B2
  申请人：——

  公开号：US7329682B2

  公开（公告）日：2008-02-12
• [EN] FLUORESCENT CELLULAR MARKERS<br/>[FR] MARQUEURS CELLULAIRES FLUORESCENTS
  申请人：BEATRIZ ZAYAS BEATRIZ

  公开号：WO2010135751A2

  公开（公告）日：2010-11-25

  A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38(7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrobenzothiazolo[3,2-a] quinolinium chloride), ABQ-38 (3-amino-7-ethylbenzimidazo[3,2-a]quinolinium chloride), and ABQ-95(3-amino-2-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride) wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage and caspases 3 and 7 activation, cellular organelles binding and damage, and a marker due to the auto-fluorescent properties.