azane;9H-fluorene | 64294-96-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: azane;9H-fluorene
• CAS: 64294-96-8
• 化学式: C13H13N
• 分子量: 183.25
• InChiKey: IBWFYDFRGAHCDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Polymeric Reagents Comprising a Terminal Vinylic Group and Conjugates Formed Therefrom
  申请人：Culbertson Sean M.

  公开号：US20100048707A1

  公开（公告）日：2010-02-25

  The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

  本发明提供了具有可降解连接的共轭物和用于制备这种共轭物的高分子试剂。还提供了制备高分子试剂和共轭物的方法，以及用于给予共轭物和组成物的方法。
• POLYMERIC REAGENTS COMPRISING A TERMINAL VINYLIC GROUP AND CONJUGATES FORMED THEREFROM
  申请人：Culbertson Sean M.

  公开号：US20120318701A1

  公开（公告）日：2012-12-20

  The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

  本发明提供了具有可降解连接的共轭物和用于制备这种共轭物的高分子试剂。还提供了制备高分子试剂和共轭物的方法，以及给予共轭物和组合物的方法。
• Propanobicyclic amine derivatives for CNS disorders
  申请人：G.D. Searle & Co.

  公开号：EP0449301A1

  公开（公告）日：1991-10-02

  Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula wherein each of R1, R2, R3, R4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R3 and R4 may be taken together to form oxo; wherein each of R9, R10, R", R12, R13 and R14 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, phenalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from wherein R15 is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl; wherein each of R16 and R17 is independently selected from hydrido, hydroxy, alkyl, phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro; wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R3, R4, ring-position two, ring-position three and ring-position four; or the pharmaceutically-acceptable salts thereof.

  某些丙双环胺化合物用于治疗中枢神经系统疾病，如精神病、抽搐、肌张力障碍和脑缺血。特别感兴趣的化合物式如下 其中 R1、R2、R3、R4、Y 和 Z 中的每一个都独立地选自氢rido、羟基、烷基、环烷基、环烷基烷基、苯烷基、苯基、烷氧基、苯氧基、苯烷氧基、烷氧基烷基、卤代、卤代烷基和羟基烷基；其中 R3 和 R4 可以一起形成氧代； 其中 R9、R10、R"、R12、R13 和 R14 中的每一个都独立选自氢化烷基、烷基、环烷基、羟基烷基、氟代烷基、环烷基烷基、烷氧基烷基、苯基烷基和苯基； 其中含氮环杂环分子内的 G 选自以下各项 其中 R15 选自氢基、烷基、环烷基、环烷基烷基、苯基、苯烷基、烷氧基烷基和羟基烷基； 其中 R16 和 R17 各自独立地选自氢基、羟基、烷基、苯烷基、苯基、烷氧基、氟烷基和氟； 其中 m 是一个或两个； 其中 p 是选自 0 到 4（包括 4）的数字；其中 q 和 r 中的每一个都是独立选自 1 到 3（包括 3）的数字，但条件是 q 和 r 的总和是 3 到 6（包括 6）的数字；进一步的条件是含氮环杂环分子必须连接在选自 R3、R4、环位置 2、环位置 3 和环位置 4 的一个位置上；或其药学上可接受的盐。
• Ethanobicyclic amine derivatives for CNS disorders
  申请人：G.D. Searle & Co.

  公开号：EP0455195A2

  公开（公告）日：1991-11-06

  Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula wherein each of R¹, R², R³, R⁴, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, phenalkyl, phenyl, alkoxy, phenoxy, phenalkoxy, alkoxyalkyl, halo, haloalkyl and hydroxyalkyl; wherein R³ and R⁴ may be taken together to form oxo; wherein each of R⁵, R⁶, R⁷, R⁸, R⁹ and R¹⁰ is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, cycloalkylalkyl, alkoxyalkyl, phenalkyl and phenyl; wherein G within the nitrogen-containing cyclohetero moiety is selected from wherein R¹¹ is selected from hydrido, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, phenalkyl, alkoxyalkyl and hydroxyalkyl; wherein each of R¹² and R¹³ is independently selected from hydrido, hydroxy, alkyl, phenalkyl, phenyl, alkoxy, fluoroalkyl and fluoro; wherein m is one or two; wherein p is a number selected from zero through four, inclusive; wherein each of q and r is a number independently selected from one through three, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive; with the further proviso that the nitrogen-containing cyclohetero moiety must be attached at one position selected from R³, R⁴, ring-position two, and ring-position three; or the pharmaceutically-acceptable salts thereof.

  某些乙双环胺化合物用于治疗中枢神经系统疾病，如精神病、抽搐、肌张力障碍和脑缺血。特别值得关注的化合物式如下 其中 R¹、R²、R³、R⁴、Y 和 Z 中的每一个都独立地选自肼基、羟基、烷基、环烷基、环烷基烷基、苯烷基、苯基、烷氧基、苯氧基、苯烷氧基、烷氧基烷基、卤代、卤代烷基和羟基烷基；其中 R³ 和 R⁴ 可以一起形成氧代； 其中 R⁵、R⁶、R⁷、R⁸、R⁹ 和 R¹⁰ 各自独立地选自氢基、烷基、环烷基、羟基烷基、氟烷基、环烷基烷基、烷氧基烷基、苯基和苯基； 其中含氮环杂环分子中的 G 选自以下各项 其中 R¹¹ 选自氢基、烷基、环烷基、环烷基烷基、苯基、苯烷基、烷氧基烷基和羟基烷基； 其中 R¹² 和 R¹³ 各自独立地选自氢基、羟基、烷基、苯烷基、苯基、烷氧基、氟烷基和氟； 其中 m 为 1 或 2； 其中 p 为选自 0 至 4（包括 4）的数字；其中 q 和 r 中的每一个都是独立选自 1 到 3（包括 3）的数字，但条件是 q 和 r 的总和是 3 到 6（包括 6）的数字；进一步的条件是含氮环杂环分子必须连接在选自 R³、R⁴、环位置 2 和环位置 3 的一个位置上；或其药学上可接受的盐。
• CONJUGATED POLYMER, INSOLUBILIZED POLYMER, ORGANIC ELECTROLUMINESCENT DEVICE MATERIAL, COMPOSITION FOR ORGANIC ELECTROLUMINESCENT DEVICE, METHOD FOR PRODUCING POLYMER, ORGANIC ELECTROLUMINESCENT DEVICE, ORGANIC EL DISPLAY, AND ORGANIC EL ILLUMINATOR
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2270069A1

  公开（公告）日：2011-01-05

  An object of the present invention is to provide a conjugated polymer which has a high hole transportability and is excellent in solubility and depositability. Another object of the present invention is to provide an organic electroluminescence element which is capable of low voltage driving and has a high luminous efficiency and drive stability. The conjugated polymer of the present invention is a conjugated polymer containing a specific structure as the repeating unit, where the conjugated polymer contains an insolubilizing group as a substituent, the weight average molecular weight (Mw) is 20,000 or more and the dispersity (Mw/Mn) is 2.40 or less.

  本发明的一个目的是提供一种共轭聚合物，该聚合物具有较高的空穴传输性，并具有出色的可溶性和沉积性。本发明的另一个目的是提供一种有机电致发光元件，它能够低压驱动，并具有高发光效率和驱动稳定性。本发明的共轭聚合物是一种含有特定结构作为重复单元的共轭聚合物，其中共轭聚合物含有不溶解基团作为取代基，重量平均分子量（Mw）为 20,000 或以上，分散度（Mw/Mn）为 2.40 或以下。