N-{(2Z)-3-(4-methylphenyl)-2-[(4-methylphenyl)imino]-4-phenyl-2,3-dihydro-1,3-thiazol-5-yl}acetamide | 1017523-75-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-{(2Z)-3-(4-methylphenyl)-2-[(4-methylphenyl)imino]-4-phenyl-2,3-dihydro-1,3-thiazol-5-yl}acetamide
• 英文别名: N-[3-(4-methylphenyl)-2-(4-methylphenyl)imino-4-phenyl-1,3-thiazol-5-yl]acetamide
• CAS: 1017523-75-9
• 化学式: C₂₅H₂₃N₃OS
• 分子量: 413.543
• InChiKey: IEEZUCGHUDLAME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-{(2Z)-3-(4-methylphenyl)-2-[(4-methylphenyl)imino]-4-phenyl-2,3-dihydro-1,3-thiazol-5-yl}acetamide 在 盐酸 、 水 、 碳酸氢钠 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以81%的产率得到5-Phenyl-2-thioxo-1,3-di-p-tolyl-imidazolidin-4-one
  参考文献：
  名称：

  Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

  摘要：

  N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N'-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

  DOI：

  10.1134/s1070363208070268
• 作为产物：
  描述：

  、 1,3-二对甲苯基-2-硫脲 在 水 、 碳酸氢钠 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 25.0h， 以56%的产率得到N-{(2Z)-3-(4-methylphenyl)-2-[(4-methylphenyl)imino]-4-phenyl-2,3-dihydro-1,3-thiazol-5-yl}acetamide
  参考文献：
  名称：

  Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas

  摘要：

  N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N'-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.

  DOI：

  10.1134/s1070363208070268

文献信息

• Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas
  作者：A. G. Balya、A. N. Chernega、S. A. But、A. N. Vasilenko、V. S. Brovarets、B. S. Drach

  DOI：10.1134/s1070363208070268

  日期：2008.7

  N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides react under mild conditions with thiourea, N-alkyl-and N-arylthioureas, and various N,N'-disubstituted thioureas, following the Hantzsch reaction scheme. The reactions are selective, and the resulting 2,5-diamino-1,3-thiazole derivatives undergo recyclization acid followed by hydrolysis to give substituted 2-thiohydantoins on heating with hydrochloric acid in ethanol.