dimethyl 3-amino-6-methyl-4-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2,5-dicarboxylate | 445221-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: dimethyl 3-amino-6-methyl-4-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2,5-dicarboxylate
• 英文别名: Dimethyl 3-amino-6-methyl-4-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2,5-dicarboxylate
• CAS: 445221-19-2
• 化学式: C₁₈H₁₈N₂O₄S
• 分子量: 358.418
• InChiKey: DWOKNGJWNYUFTQ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  methyl 5-cyano-2-methyl-6-methylsulfanyl-4-phenyl-1,4-dihydropyridine-3-carboxylate 在 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以93%的产率得到dimethyl 3-amino-6-methyl-4-phenyl-4,7-dihydrothieno[2,3-b]pyridine-2,5-dicarboxylate
  参考文献：
  名称：

  Synthesis Of 6- Alkoxycarbonylmethylsulfanyl-5-Cyano-2- Methyl-4-Phenyl-1,4-Dihydropyridine-3-Carboxylates

  摘要：

  6-Alkoxycarbonylmethylsulfanyl-5-cyano-2-methyl-4-phenyl 1,4-dihydropyridine-3-carboxylates 3 as a more lipophilic derivatives of the biologically active 6-methylsulfanyl-1,4-DHP-3-carboxylates 2 have been prepared by the alkylation of 1,4-dihydropyridine-6-thiolates 1 with alkyl bromoacetates. Reactivity of 2 with KOH/H2O was investigated.

  DOI：

  10.1515/hc.2009.15.4.297