11α-Hydroxy-Δ⁴-estren-17-on | 38932-91-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 11α-Hydroxy-Δ⁴-estren-17-on
• CAS: 38932-91-1
• 化学式: C₁₈H₂₆O₂
• 分子量: 274.403
• InChiKey: WSLMGVBRIJUEFN-JVSYPLCOSA-N

反应信息

• 作为反应物：
  描述：

  11α-Hydroxy-Δ⁴-estren-17-on 在 N,N-二乙基(2-氯-1,1,2-三氟乙基)胺 作用下， 以 二氯甲烷 为溶剂， 生成 4,9(11)-Estradien-17-on
  参考文献：
  名称：

  Strategy in drug reseabch. Synthesis and study of the psogestational and ovulation inhibitory activity of a series of 11β-substituted-17α-ethynyl-4-estren-17β-ols

  摘要：

  Using the strategy based on the Hansch method which analyses effects of substituents on biological activity in terms of their hydrophobic, electronic and steric effects we selectively synthesised a series of 11beta-substituted-17alpha-ethynyl-4-estren-17beta-ols that combine ease of synthesis with good discrimination between these factors aiming at finding the compounds with optimum biological activity in that series. The compounds were tested quantitatively in the Clauberg test (rabbit) and the ovulation inhibition test (rat). The differences in biological activity could reasonably be correlated with two steric effects introduced by the 11beta-substituent. These were a change in the overall shape of the 11beta-substituent and the angular methyl group, and direct steric hindrance of the steroid-receptor protein binding. Some exceptions were found possibly due to metabolic conversion of these compounds to the corresponding 11beta-substituted-17alpha-ethynyl-1,3,5(10)-estra-triene-3,17beta-diols.

  DOI：

  10.1016/0039-128x(77)90095-2
• 作为产物：
  描述：

  11α-Hydroxy-Δ⁴-estren-3,17-dion-3-ethylendithioacetal 生成 11α-Hydroxy-Δ⁴-estren-17-on
  参考文献：
  名称：

  19-nor系列中的11-亚烷基类固醇

  摘要：

  已经合成了许多11-亚甲基取代的雌烯和19-正孕烯。另外，已经制备了一些11-（E）-亚乙基雌烯。提出了建立亚乙基取代基构型的证据。

  DOI：

  10.1002/recl.19750940203