p-methoxyphenyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside | 1374633-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: p-methoxyphenyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside
• 英文别名: (3aS,4R,6S,7R,7aR)-6-(4-methoxyphenoxy)-2,2-dimethyl-4-(trityloxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-7-ol
• CAS: 1374633-06-3
• 化学式: C₃₅H₃₆O₇
• 分子量: 568.667
• InChiKey: RMAOWPRUDPEVIH-IZDBAANZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  p-methoxyphenyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside 在 甲醇 、 N-碘代丁二酰亚胺 、 ammonium cerium (IV) nitrate 、 硫酸 、 水 、 silver trifluoromethanesulfonate 、 sodium hydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 8.5h， 生成
  参考文献：
  名称：

  Synthesis of tetra- and hexasaccharide fragments corresponding to the O-antigenic polysaccharide of Klebsiella pneumoniae

  摘要：

  The preparation of linear tetra- (1) and hexasaccharides (2), containing the repeating unit [-> 3)-beta-Galf-(1 -> 3)-alpha-Galp-(1 -> ] present in the O-polysaccharide of the lipopolysaccharide of Klebsiella pneumoniae is described. The key step in their synthesis is the alpha-selective galactopyranosylation of 3-OH di- and tetrasaccharide acceptors (20 and 22) with a disaccharide trichloroacetimidate donor 19 in the presence of trimethylsilyl triflate in a diethyl ether-CH2Cl2 mixture as solvent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.074
• 作为产物：
  描述：

  三苯基氯甲烷 在 吡啶 、 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 32.0h， 生成 p-methoxyphenyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside
  参考文献：
  名称：

  Synthesis of tetra- and hexasaccharide fragments corresponding to the O-antigenic polysaccharide of Klebsiella pneumoniae

  摘要：

  The preparation of linear tetra- (1) and hexasaccharides (2), containing the repeating unit [-> 3)-beta-Galf-(1 -> 3)-alpha-Galp-(1 -> ] present in the O-polysaccharide of the lipopolysaccharide of Klebsiella pneumoniae is described. The key step in their synthesis is the alpha-selective galactopyranosylation of 3-OH di- and tetrasaccharide acceptors (20 and 22) with a disaccharide trichloroacetimidate donor 19 in the presence of trimethylsilyl triflate in a diethyl ether-CH2Cl2 mixture as solvent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.074

文献信息

• Synthetic Antigen Constructs Against Campylobacter Jejuni
  申请人：Guerry Patricia

  公开号：US20160144017A1

  公开（公告）日：2016-05-26

  The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni ( C. jejuni ) in a subject comprising one or more monosaccharides comprising one or more MeOPN moieties. Specifically, the invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni ( C. jejuni ) in a subject comprising one or more MeOPN→6 Gal monosaccharides. The invention also relates to compositions comprising the immunogenic synthetic constructs and methods of inducing an immune response against C. jejuni in a subject comprising administering the immunogenic synthetic constructs, and/or compositions comprising the immunogenic synthetic construct, to the subject.

  本发明涉及一种免疫原性合成构造体，其能够诱导受体内的一种或多种单糖含有一种或多种MeOPN基团，从而诱导对弯曲菌（C. jejuni）的免疫反应。具体而言，本发明涉及一种免疫原性合成构造体，其能够诱导受体内的一种或多种MeOPN→6 Gal单糖含有对弯曲菌（C. jejuni）的免疫反应。本发明还涉及包含该免疫原性合成构造体的组合物以及诱导受体对C. jejuni进行免疫反应的方法，包括向受体注射该免疫原性合成构造体和/或包含该免疫原性合成构造体的组合物。
• US9925254B2
  申请人：——

  公开号：US9925254B2

  公开（公告）日：2018-03-27